NIOSH Pocket Guide to Chemical Hazards

Chloroform CAS 67-66-3
CHCl3 RTECS FS9100000
Synonyms & Trade Names
Methane trichloride, Trichloromethane
DOT ID & Guide
1888 151
NIOSH REL: Ca ST 2 ppm (9.78 mg/m3) [60-minute] See Appendix A
OSHA PEL†: C 50 ppm (240 mg/m3)
IDLH Ca [500 ppm] Conversion 1 ppm = 4.88 mg/m3
Physical Description
Colorless liquid with a pleasant odor.
MW: 119.4
BP: 143°F
FRZ: -82°F
Sol(77°F): 0.5%
VP: 160 mmHg
IP: 11.42 eV

Sp.Gr: 1.48
Fl.P: NA

Noncombustible Liquid
Incompatibilities & Reactivities
Strong caustics; chemically-active metals such as aluminum or magnesium powder, sodium & potassium; strong oxidizers [Note: When heated to decomposition, forms phosgene gas.]
Measurement Methods
NIOSH 1003
Personal Protection & Sanitation
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Eyewash, Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Soap wash promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations NIOSH
At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin; dizziness, mental dullness, nausea, confusion; headache, lassitude (weakness, exhaustion); anesthesia; enlarged liver; [potential occupational carcinogen]
Target Organs Liver, kidneys, heart, eyes, skin, central nervous system

Cancer Site [in animals: liver & kidney cancer]