NIOSH Pocket Guide to Chemical Hazards

Epichlorohydrin CAS 106-89-8
C3H5OCl RTECS TX4900000
Synonyms & Trade Names
1-Chloro-2,3-epoxypropane; 2-Chloropropylene oxide; gamma-Chloropropylene oxide
DOT ID & Guide
2023 131P
Exposure
Limits
NIOSH REL: Ca See Appendix A
OSHA PEL: TWA 5 ppm (19 mg/m3) [skin]
IDLH Ca [75 ppm] Conversion 1 ppm = 3.78 mg/m3
Physical Description
Colorless liquid with a slightly irritating, chloroform-like odor.
MW: 92.5
BP: 242°F
FRZ: -54°F
Sol: 7%
VP: 13 mmHg
IP: 10.60 eV

Sp.Gr: 1.18
Fl.P: 93°F
UEL: 21.0%
LEL: 3.8%

Class IC Flammable Liquid: Fl.P. at or above 73F and below 100F.
Incompatibilities & Reactivities
Strong oxidizers, strong acids, certain salts, caustics, zinc, aluminum, water [Note: May polymerize in presence of strong acids and bases, particularly when hot.]
Measurement Methods
NIOSH 1010; OSHA 7
Personal Protection & Sanitation
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet (flammable)
Change: No recommendation
Provide: Eyewash, Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Soap wash immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations NIOSH
At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor and acid gas canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin with deep pain; nausea, vomiting; abdominal pain; respiratory distress, cough; cyanosis; reproductive effects; [potential occupational carcinogen]
Target Organs Eyes, skin, respiratory system, kidneys, liver, reproductive system

Cancer Site [in animals: nasal cancer]
See also: INTRODUCTION