NIOSH Pocket Guide to Chemical Hazards

Isobutyronitrile CAS 78-82-0
(CH3)2CHCN RTECS TZ4900000
Synonyms & Trade Names
Isopropyl cyanide, 2-Methylpropanenitrile, 2-Methylpropionitrile
DOT ID & Guide
2284 131
Exposure
Limits
NIOSH REL: TWA 8 ppm (22 mg/m3)
OSHA PEL: none
IDLH N.D. Conversion 1 ppm = 2.83 mg/m3
Physical Description
Colorless liquid with an almond-like odor. [Note: Forms cyanide in the body.]
MW: 69.1
BP: 219°F
FRZ: -97°F
Sol: Slight
VP(130°F): 100 mmHg
IP: ?

Sp.Gr: 0.76
Fl.P: 47°F
UEL: ?
LEL: ?

Class IB Flammable Liquid: Fl.P. below 73F and BP at or above 100F.
Incompatibilities & Reactivities
Oxidizers, reducing agents, strong acids & bases
Measurement Methods
NIOSH 1606 (adapt)
Personal Protection & Sanitation
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet (flammable)
Change: No recommendation
Provide: Eyewash, Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Soap flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations NIOSH
Up to 80 ppm: (APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)/(APF = 10) Any supplied-air respirator
Up to 200 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode/(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)
Up to 400 ppm: (APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)/(APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece
Up to 1000 ppm: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, nose, throat; headache, dizziness, lassitude (weakness, exhaustion), confusion, convulsions; dyspnea (breathing difficulty); abdominal pain, nausea, vomiting
Target Organs Eyes, skin, respiratory system, central nervous system, cardiovascular system
See also: INTRODUCTION