NIOSH Pocket Guide to Chemical Hazards

4,4'-Methylenedianiline CAS 101-77-9
CH2(C6H4NH2)2 RTECS BY5425000
Synonyms & Trade Names
4,4'-Diaminodiphenylmethane; para, para'-Diaminodiphenyl-methane; Dianilinomethane; 4,4'-Diphenylmethanediamine; MDA
DOT ID & Guide
NIOSH REL: Ca See Appendix A
OSHA PEL: [1910.1050] TWA 0.010 ppm ST 0.100 ppm
IDLH Ca [N.D.] Conversion
Physical Description
Pale-brown, crystalline solid with a faint, amine-like odor.
MW: 198.3
BP: 748°F
MLT: 198°F
Sol: 0.1%
VP(77°F): 0.0000002 mmHg
IP: 10.70 eV

Sp.Gr: 1.06 (Liquid at 212°F)
Fl.P: 374°F
UEL: ?
LEL: ?

Combustible Solid
Incompatibilities & Reactivities
Strong oxidizers
Measurement Methods
NIOSH 5029
Personal Protection & Sanitation
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated/Daily
Remove: When wet or contaminated
Change: Daily
Provide: Eyewash, Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Soap wash immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations NIOSH
At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having a high-efficiency particulate filter/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes; jaundice, hepatitis; myocardial damage; in animals: heart, liver, spleen damage; [potential occupational carcinogen]
Target Organs Eyes, liver, cardiovascular system, spleen

Cancer Site [in animals: bladder cancer]
See also: INTRODUCTION   See ICSC CARD: 1111