Experimental and Computational Biomechanics of Human Blood Cell Diseases
Ming Dao (MIT), George Karniadakis (Brown University), Subra Suresh (MIT)
Eringen Medal Symposium in honor of G. Ravichandran
Mon 9:00 - 10:30
Salomon 001
This presentation will provide a review of our recent work on experimental and computational studies of single-cell biomechanics and cell biorheology, as well as their connections to several human diseases. A variety of independent experimental methods that probe cell biophysical properties will be described covering the full spectrum of a perfectly healthy state to a completely pathological state. The single-cell experiments will be accompanied by experimental studies of biorheology involving large cell populations by recourse of microfluidic devices that investigate healthy and disease states. Detailed computational models involving dissipative particle dynamics (DPD) simulations will be presented to address systematically a variety of fundamental questions on the connections between cell biomechanics and disease states involving Plasmodium falciparum malaria and hereditary blood disorders.