The history of IVF and ET dates
back as early as the 1890's when Walter Heape successfully transferred
embryos between rabbits, long before the applications to human fertility
were even suggested. However, it was not until 1959 that indisputable
evidence of IVF was obtained by Chang in experiments on rabbits. Professionals
in the fields of microscopy, embryology, and anatomy laid the foundations
for their achievement. The recent rapid growth of IVF and ET techniques
are further supported by the social and scientific climate favorable
to its continuation. Walter Heap's work together with other major advances
throughout the last century, led some researchers to consider the possibility
of IVF and ET in humans. In humans, IVF was developed for the treatment
of tubal infertility but it shows great potentials for other applications.
Numerous modifications were made during the development of IVF and ET
in humans: refinement of fertilization and embryo culture media; earlier
transfer of the embryo; improvements in equipments; use of reduced number
of spermatozoa in fertilization dish. Although debate centered largely
on the moral and legal issues of the IVF and ET procedures have escalated
during its progress, in the near future IVF and EF will be viewed as
a valuable infertility, as well as shed more light on the knowledge
about the earliest stages of human development.