Photo: Carlson
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Precursors- Primordial Germ Cells: Germ-Line-Inducing Factors
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| Germ-line-inducing factors present near the junction between the trophoblast and ICM play a role in germ-line development. Two factors: transforming growth factor ß (TGFß) and bone morphogenic protein 4 (BMP4) absent from the developing embryo would completely lack both an allantois and PGCs [1]. | |
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| References |
Photo: Carlson
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| BMP4, secreted by extraembryonic mesoderm, induces the fate of pluripotent proximal epiblast cells to become either PGCs or allantois cells. The related protein, BMP8b, (extraembryonic ectoderm derived) is at least one factor functioning in collaboration with BMP4 to control PGC development [1]. | |||