Biology 105
Eukaryotic Cell Biology

October 31, 2006 "Cell-Cycle Regulation of Vertebrate DNA Replication by Proteolysis"

Today's Handouts: Reading List (PDF)

Prof. Johanes Walter
Special Guest Lecture (12 noon in Eddy Auditorium)
Lecture Slides (ppt)

Click to Visit Dr. Walter's Lab at Harvard

Required Reading:

Arias & Walter (2005) PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nature Cell Biology 8: 84-90.

Jin et al (2006) A Family of Diverse Cul4-Ddb1-Interacting Proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Molecular Cell 23: 709-721. (PDF)

Click for music from Johannes Walter
(not the same guy, but still pretty nice)