Biology 105
Eukaryotic Cell Biology

November 2, 2006 Centromeres & Telomeres

Today's Handouts: Lecture Outline Complete Reading List (PDF)

Lectures Slides available via WebCT
(Note: Slides will be available with 24 hours of lecture)

Required Reading:

Textbook: Alberts et al (2002) Molecular Biology of the Cell pp. 226-8, 263-6, 1347.

(1) Centromeres:

Amor DJ, Bentley K, Ryan J, Perry J, Wong L, Slater H, Choo KH. (2004). Human centromere repositioning "in progress". Proc Natl Acad Sci U S A. 101: 6542-7.

(2) Telomeres:

A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, G.B. Morin, C.B. Harley, J.W. Shay, S. Lichtsteiner, W.E. Wright (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352.

A. Taggart, S.-C. Teng and V.A. Zakian (2002) Est1p as a cell cycle-regulated activation of telomere-bound telomerase. Science 297: 1023-1026.

A.K.P. Taggart and V.A. Zakian (2003) Telomerase: what are the Est proteins doing? Curr. Opin. Cell Biol. 15: 275-280. (SKIM)

Cech TR (2004) Beginning to understand the end of the chromosome. Cell 116: 273-279.