Biology 105
Eukaryotic Cell Biology

September 21, 2006 Protein Targeting

Today's Handouts: Lecture Outline Complete Reading List (PDF)

Lecture Slides available via WebCT
(Note: Slides will be available with 24 hours of lecture)

Required Reading:

Alberts et al (2002) Mol. Biology of the Cell
pp. 659-669 (compartments); 689-709 (ER function).

Leslie (2005) Lost in Translation - The Signal Hypothesis. JCB 170: 338. (a Brief History of the Signal Hypothesis)

Muñiz, Morsonne, and Reizman (2001) Protein Sorting upon Exit from the Endoplasmic Reticulum. Cell 104: 313-320.

Alder et al (2005) The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum. JCB 168:389-399.

Wickner & Scheckman (2005) Protein translocation across biological membranes. Science 310: 1452-1456.

 

From the MBOC CD: Features 12.2 (ER dynamics); 12.3 (ER-ribosome translocon); 12.5 (Rough ER in the TEM); 13.6 & 13.7 (Pancreas TEM)