MMR Vaccine

Schedule:

 

        Children

2 doses:İ First at 12-15 months (NOT before 12 months)

İİİİİ İİİİİİİİ Second can be received at any age, as long as at least 28 days have passed

since first dose.İ Recommended age is 4-6 years

        Adults 18 and up, born after 1956, who do not have record of MMR vaccination or disease, should get at least 1 dose of MMR

** Other vaccines may be given at the same time as MMR

 

Contraindications:

 

        Severe allergic reaction to gelatin, neomycin or a previous dose of MMR

        Moderateİ to severe illness at time vaccination is scheduled

        Pregnancy, or likelihood of pregnancy within next 3 months

 

Conditions for which one should talk to a doctor before vaccination:

 

        HIV infection or other immunosuppression

        Taking drugs that suppress the immune system (like steroids) for 2 weeks or longer

        Cancer

        Receiving cancer treatment, including radiation and chemotherapy

        Low platelet count

        Recent recipient of a blood transfusion

 

Risks:İ

 

        Mild ñ usually occur 7-12 days after vaccination

Fever (1 in 6)

Mild rash (1 in 20)

Swelling of glands in neck and cheek areas (rare)

        Moderate

Fever induced seizures (1 in 3000)

Temporary pain and stiffness in joints (1 in 4 teenage or adult women)

Temporary low platelet count (1 in 30,000)

        Severe ñ All except allergic reaction are so rare that it has been impossible to

determine that they are actually caused by the vaccine:

İİİİİİİİİİİ Allergic Reaction (1 in 1 million)

İİİİİİİİİİİ Deafness

İİİİİİİİİİİ Long term seizures

İİİİİİİİİİİ Coma

İİİİİİİİİİİ Brain Damage

** Getting MMR vaccine is much safer than getting any of the diseases against which it protects

 

Coverage:

 

        National vaccination coverage for one or more doses of a Measles Containing Vaccine (MCV)ß among children 19-35 mos. (born 2/95-5/97), 1995-1998 (National Immunization Survey):

 

Yearİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ % Vaccinated (95% Confidence Interval (CI))
1995İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 89.9 (
± 0.7)

1996                                                                                                                                            90.7 (± 0.5)

1997                                                                                                                                            90.5 (± 0.5)

1998                                                                                                                                            92.1 (± 0.6)*

* In 1998, vaccine coverage for an MCV was higher than for any other vaccine in the survey

İİİİİİ * 1998 vaccine coverage in Rhode Island for an MCV was 96.5% (± 2.2)

 

        Estimated vaccine coverage with one or more doses of an MCV among children 19-35 mos. (born 2/95-5/97), by race/ethnicity, in U.S. (National Immunization Survey, 1998):

İİİİİİİİİİ

İİİİ Race/ Ethnicityİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ % Vaccinated (95%CI)

White Non-Hispanicİİ İİİİİİİİİİİİİ İİİİİİİİİİİİİİİİİİİİİİİ 93.3 (± 0.7)İ İİ

Black Non-Hispanicİİ İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 88.9 (± 2.0)

Hispanic (of any race)İİİİİİİİ İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 91.2 (± 1.6)

American Indian/Alaska Nativeİ İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 91.4 (± 7.0)

Asian/Pacific Islanderİİİİİİİİ İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 92.4 (± 3.3)

 

        1998 Vaccine Coverage with one or more doses of an MCV among children 19-35 mos. living below the poverty level (National Immunization Survey):

 

Regionİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ % Vaccinated (95% CI)İİİİİİİİİİİİİİİİİİİİİİ Percent in Poverty

United Statesİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 90.2 (± 1.3)İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 21.6

New Englandİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 91.6 (± 4.2)İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 15.6

Rhode Islandİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 91.1 (± 7.9)İİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİİ 20.0

 

The average annual number of measles cases in 1958-1962 (the 5

İİİİİİİİİİİİİİİİİİİİİİİ years before vaccine licensure): 503,282. U.S. cases in 1998: 89.

İİİİİİİİİİİİİİİİİİİİİİİ The number of mumps cases in 1968 (the year reporting began and

İİİİİİİİİİİİİİİİİİİİİİİ the first year after licensure): 152,209. U.S. cases in 1998: 606.

İİİİİİİİİİİİİİİİİİİİİİİ The average annual number of rubella cases in 1966-1968 (the 3

İİİİİİİİİİİİİİİİİİİİİİİ years before vaccine licensure): 47,745. U.S. cases in 1998: 345.

İİİİİİİİİİİİİİİİİİİİ İİİThe estimated average annual number of cases of congenital rubella

İİİİİİİİİİİİİİİİİİİİİİİ syndrome in 1966-1968 (the 3 years before vaccine licensure):

İİİİİİİİİİİİİİİİİİİİİİİ 823. U.S. cases in 1998: 5.



ß MMR is the most commonly administered MCV.

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This web site was developed by undergraduate students at Brown University as a project for a course in vaccine development (Bio 160). An effort has been made to present information on the prevalent opinions available at this time.  References to published articles and acknowledgements of other sources are cited in the text.  The authors of this web site are not certified medical professionals.  Biomedical research and clinical medicine are constantly evolving fields, thus it is possible that significant advances in research and treatments will come into existence following posting of this web site.