Clinical Features:

 

…        Prodrome ñ Incubation period 14-18 days

ÝNon-specific symptoms, including headache, low grade fever,

Ý malaise, anorexia

…        ParotitisÝ -- Inflammation of the Parotid gland

ÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝ Most common manifestation

ÝÝÝÝÝ ÝÝÝÝÝ ÝOccurs in 30-40% of infected patients

ÝÝÝÝÝ ÝÝÝÝÝ ÝTends to occur in first 2 days

ÝÝÝÝÝ ÝÝÝÝÝ ÝNoted as earache or tenderness at angle of jaw

Can be unilateral or bilateral; can affect single or multiple glands

ÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝÝ Symptoms being to decrease after 1 week

ÝÝÝÝÝÝÝÝÝÝÝ ** 20% of Mumps infections are asymptomatic, and another 40-50% may

ÝÝÝÝ have only nonspecific symptoms (i.e. cold-like)

 

Complications:

 

…        Central Nervous System (CNS) involvement --

Aseptic meningitis: asymptomatic, in 50-60% of patients

Symptomatic meningitis: resolves without sequelae in 3-10 days, in 15%

of patients;Ý boys affected more commonly than girls (3:1 ratio);

parotitis absent in 50% of such cases

 

…        Orchitis ñ testicular inflammation, in 20-50% of postpubertal males

 

…        Oophoritis ñ ovarian inflammation, in 5% of postpubertal females

 

…        Pancreatitis ñ in 2-5% of reported cases, usually occurs without parotitis;

ÝÝÝÝÝÝ association with Diabetes Mellitus, but no causal relationship determined

 

…        Deafness ñ 1 in 20,000 reported cases; one of leading causes of acquired

ÝÝÝÝÝÝ sensorineural deafness in childhood; unilateral in 80% of cases

 

…        Death ñ 1-3 per 10,000 cases in recent years