SARS-CoV: Disease Pathology
Disease Pathology
Lung Pathology

Syncytia
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Lung Pathology

  • Inflammatory exudation in alveoli and interstitial spaces
  • Monocytic and lymphocytic infiltration of lung tissue
  • Hyperplasia of alveolar epithelial cells and fibrous tissue
  • Fibrosis of lung tissue

Chest X-rays of SARS Patient
Chest X-rays of SARS Patient
(http://www.blackwell-synergy.com/servlet/useragent?
func=synergy&synergyAction=showFullText&doi=10.1046/j.1440-
1843.2003.00525.x&area=production&prevSearch=allfield%3A%28SARS%29
)


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Syncytia

Syncytia are also known as multi-nucleated giant cells. They result when neighboring cells fuse with one another. Syncytia have been observed in the lungs of SARS-infected patients.


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Brown University, Providence, Rhode Island
Bio160: Development of Vaccines to Infectious Diseases
Shirley Chan, H. Jonathan Chong, Tevis Howard, Sarah Kimball, Michael Soule
April 2004