BI160: Development of Vaccines to Infectious Diseases

REFERENCES

BACKGROUND

[1] - San Diego Natural History Museum Field Guide - http://www.sdnhm.org/fieldguide/zoonoses/lyme.html

[2] - The Nation's Voice on Medical Illness - http://bipolar.nami.org/update/update6.htm#lymed

[3] - Lyme Disease: Epidemiology - http://www.cdc.gov/ncidod/dvbid/lyme/epi.htm

[4] - Division of Vector-Borne Infection- Lyme Disease: http://www.apic.org/

[5] - Overview of Lyme Disease: http://www.angelfire.com/biz/romarkaraoke/Sh07303.html

[6] - Common Topics-Lyme Disease: http://members.tripod.com/tntlyme/topic.htm#BI

VECTOR

[1] - http://www.aldf.com/DeerTickEcology.asp

[2] - http://www.aldf.com/FourPosterDeerTreatmentBaitStation.htm

[3] - Montgomery, Ruth R.; Lusitani, Denise; de Boisfleury Chevance, Anne; Malawista, Stephan E. Tick Saliva Reduces Adherence and Area of Human Neutrophils. Infection and Immunity, May 2004, p. 2989-2994, Vol. 72, No. 5.

[4] - Gillespie, R. Dean; Dolan, Marc C.; Piesman, Joseph; Titus, Richard G. Identification of an IL-2 Binding Protein in the Saliva of the Lyme Disease Vector Tick, Ixodes scapularis. The Journal of Immunology, 2001, 166: 4319-4326.

[5] - Pal, Utpal; Yang, Xiaofeng; Chen, Manchuan; Bockenstedt, Linda K.; Anderson, John F.; Flavell, Richard A.; Norgard, Michael V.; Fikrig, Erol. OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest. 2004 January 15; 113(2): 220-230.

DISEASE

[1] - Borrelia burgdorferi Gene-Protein Index , from the Borrelia burgdorferi sensu lato Molecular Genetics Server, <http://www.pasteur.fr/recherche/borrelia/Gene_index.html>

[2] - Purser, J. E. & Norris, S. J. Correlation between plasmid content and infectivity in Borrelia burgdorferi . Proc. Natl Acad. Sci. USA 97 , 13865–13870 (2000)

[3] - Eggers, C. H. et al. Transduction by f BB-1, a bacteriophage of Borrelia burgdorferi . J. Bacteriol . 183 , 4771–4778 (2001)

[4] - Eggers, C. H. & Samuels, D. S. Molecular evidence for a new bacteriophage of Borrelia burgdorferi . J. Bacteriol . 181 , 7308–7313 (1999)

[5] - Medical Microbiology , 4th ed., Baron, Samuel , editor. Galveston , TX : University of Texas Medical Branch ; c1996. <http://www.ncbi.nlm.nih.gov/books/>

[6] - Singh , SK and Girschick, HJ. Molecular survival strategies of the Lyme disease spirochete Borrelia burgdorferi . The Lancet , Infectious Diseases, Vol 4, September 2004.

[7] - Eicken C , et al. Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi . J Biol Chem. 2002 Jun 14;277(24):21691-6. Epub 2002 Mar 28

[8] - Singh , SK and Girschick, HJ. Molecular survival strategies of the Lyme disease spirochete Borrelia burgdorferi . The Lancet , Infectious Diseases, Vol 4, September 2004.

[9] - Alaedini A, Latov N. Antibodies against OspA epitopes of Borrelia burgdorferi cross-react with neural tissue. J Neuroimmunol. 2005 Feb;159(1-2):192-5. Epub 2004 Nov 26.

[10] - http://www.emedicine.com/neuro/topic521.htm

[11] - http://www.emedicine.com/med/topic1346.htm

[12] - http://www.emedicine.com/ped/topic1331.htm

[13] - http://www.emedicine.com/med/topic1346.htm

[14] - http://www.emedicine.com/oph/topic262.htm

[15] - http://www.emedicine.com/neuro/topic521.htm

[16] - http://www.emedicine.com/neuro/topic521.htm

[17] - http://www.emedicine.com/emerg/topic588.htm

[18] - http://www.emedicine.com/neuro/topic521.htm

VACCINES

[1] - Lyme Disease Foundation, Lyme Vaccine: Hope or Hype?, September 13, 1997 . http://www.lyme.org/vaccine/vaccine.html

[2] - Steere, Allen C., et al., “Vaccination against Lyme Diesase with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein with Adjuvant.” The New England Journal of Medcine . July 1998. Vol. 339, No. 4. 209-215.

[3] - Sigal, Leonard H., et al., “A Vaccine Consisting of Recombinant Borrelia burgdorferi Outer-Surface Protein A to Prevent Lyme Disease.” The New England Journal of Medcine . July 1998. Vol. 339, No. 4. 216-222.

[4] - Croke, Cindy L., et al., “Occurrence of Severe Destructive Lyme Arthritis in Hamsters Vaccinated with Outer Surface Protein A and Challenged with Borrelia burgdorferi .” Infection and Immunity . February 2000. Vol. 68, No. 2. 658-663

[5] - Parenti, D., Croke, Cindy L., “Outer Surface Protein A and Arthritis in Hamsters.” Infection and Immunity. December 2000. Vol. 68, No. 12. 7212-7213.

[6] - Willet, T., Meyer, A., Brown, E., Huber, B., “An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope.” PNAS . Vol. 101, No. 5. 1303-1308.

Special thanks to Professor Tom Mather from University of Rhode Island for communications on the vector-based vaccine.

 

PHOTOGRAPH CREDITS

TITLE HEADER

BACKGROUND

VECTOR

DISEASE

  • Todar's Online Textbook of Bacteriology: textbookofbacteriology.net/ Lyme.html
  • Singh , SK and Girschick, HJ. Molecular survival strategies of the Lyme disease spirochete Borrelia burgdorferi . The Lancet , Infectious Diseases, Vol 4, September 2004.
  • Kuby, Immunolgy 4/e.

VACCINES

  • http://www.cnn.com/
  • Steere, Allen C., et al., “Vaccination against Lyme Diesase with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein with Adjuvant.” The New England Journal of Medicine . July 1998. Vol. 339, No. 4. 209-215.
  • Willet, T., Meyer, A., Brown, E., Huber, B., “An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope.” PNAS . Vol. 101, No. 5. 1303-1308.
 
 
TOP
 
Copyright © 2005