Adrenocortical carcinoma (microscopic)
In this case obvious anaplasia is indicative of a malignant lesion. In cases with more “benign” histological appearance, the
differentiation between adenoma and carcinoma can be difficult unless clinical metastases have been demonstrated. Features suggestive of malignancy include size (>500 grams), areas of calcification and necrosis, and gross lobulation.
Contributed by Dr. Ron DeLellis
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