Squamous cell carcinoma (non-keratinizing)


Sinonasal squamous cell carcinoma (SCC) or epidermoid carcinoma represents 3-4% of all head and neck malignant tumor.  It typically occurs in the maxillary sinus antrum, nasal cavity, and ethmoid sinus.  Two subtypes exist: 1) keratinizing and 2) non-keratinizing.  A poorly-differentiated non-keratinizing SCC is depicted here.  Many broad, interconnecting bands of neoplastic epithelium without keratinization characterizes this lesion (left).  Pleomorphic cells with loss of polarity and marked mitotic activity are present (right).


1 minute clinical correlation

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