Eosinophilic granuloma
Langerhans cell histiocytes with indistinct pale pink cytoplasm are illustrated here. The nuclei are often folded or notched. Letterer-Siwe disease, Hand-Schuller-Christian disease, and eosinophilic granulomas are considered to be the same basic disorder, Langerhans cell histiocytosis, with differing expressions. The Langerhans cells are monoclonal indicating that this disorder is probably neoplastic.
From the slide collection of the late Dr. Charles Kuhn
1 minute clinical correlation