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Larry Brown, MD

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Larry Brown

Title: Professor of Psychiatry & Human Behavior
Department: Psychiatry & Human Behavior

Larry_Brown@Brown.edu
+1 401 444 8539

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Overview | Research | Grants/Awards | Teaching | Publications

Larry Brown's current research interests focus on HIV risk and the efficacy of HIV prevention treatments among subgroups of adolescents and young adults such as those with psychiatric disorders. He is the Principal Investigator of several major projects, funded by National Institute of Memtal Health (NIMH), that focus on the relationship between psychopathology and HIV risk behaviors.

Biography

Dr. Brown is a board-certified child and adolescent psychiatrist with a particular interest in HIV and risk behaviors among adolescents and young adults. He also conducts clinical treatment trials to reduce substance use and depression for those living with HIV through the Adolescent AIDS Trials Network and is developing and testing a movile game to improve medical adherence for adolescents and young adults with HIV.

Institutions

Rih

Research Description

Adolescent HIV Prevention Laboratory
Ongoing projects, funded by NIMH and National Institute on Drug Abuse (NIDA), target HIV prevention intervenions for those for at-risk adolescents living with HIV. Studies demonstrate the impact of a family-based intervention to increase adolescent and parent communication and parental monitoring of adolescent activities. This family-based HIV prevention research is one of the first to target adolescents with severe mental illness and their families. Other studies examine interventions for juvenile offenders, media-based interventions for community youth, and interventions for those living with HIV, including the use of mobile gaming. In all studies, HIV-related knowledge, attitudes, and behaviors are targeted through both didactic and skills-based activities. The laboratory provides training in HIV clinical research for clinical psychology interns, post-doctoral fellows, psychiatrists, and other physicians. .

Awards

Phi Beta Kappa
President International Society for AIDS Education 1994-1995
Faculty Mentor Award, Department of Psychiatry and Human Behavior, Brown University, May 2006
Certificate of Excellence, Department of Psychiatry, Rhode Island Hospital, December, 2007
Psychiatry Research Mentor Award, Department of Psychiatry and Human Behavior, Brown University, May,2008
Norbert and Charlotte Rieger Award for Scientific Achievement from the American Academy of Child and Adolescent Psychiatry for the best scientific paper published in the Journal of the American Academy of Child and Adolescent Psychiatry, 2012

Affiliations

American Academy of Child and Adolescent Psychiatry.
HIV Issues Committee (1988 - present)
Chair of Committee (10/93 to 10/01)

American Medical Associations Guideline for Adolescent Preventive Services School Health Committee (1994)

American Psychiatric Association's HIV/AIDS Treatment Guidelines Workshop (1998- present)

American Public Health Association

International AIDS Society

International Society for AIDS Education

Rhode Island Medical Society

Rhode Island Psychiatry Society

Lifespan/Brown/Tufts Center for AIDS Research (CFAR)
Director of Behavioral & Social Sciences Program (2006-2011)
Co-Direcctor of the Prevention Core (2011-present)

NIMH Annual International Conference on the Role of Families in Preventing and Adapting to HIV/AIDS, Host Site and Chair Local Planning Committee, 2008

Journal of American Academy of Child and Adolescent Psychiatry (1990 - present).
Member of Editorial Board (2002 – present).

Adolescent AIDS Trials Network (NICHD), Member of Behavioral Leadership Group, 2005 - present

Funded Research

"HIV, Abuse and Psychiatric Disorders among Youth" Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Mental Health Type: R01 (MH 61149) Period: 09/30/00 to 8/31/05. This project will develop and test the efficacy of an HIV-prevention program that specifically targets the long-lasting effects of sexual abuse on safer sex behaviors among adolescents in intensive treatment settings.

"HIV Prevention for Youth with Severe Mental Illness" Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Mental Health Type: R01 (MH 63008) Period: 07/01/02 to 06/30/12. This multisite project with Emory University and the University of Illinois at Chicago (UIC)will develop and test the efficacy of a family-based intervention compared to an adolescent-only intervention and a standard care condition in changing safer sex behaviors among adolescents with psychiatric disorders.

"Family-Based HIV Prevention for Latinos. Research Supplement for Underrepresented Minorities" Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Mental Health Type: R01 (MH063008-S1) Period: 4/1/04 to 3/31/07. This supplement will allow Dr. Celia Lescano to obtain qualitative data in order to adapt a family-based HIV-prevention intervention that was developed for adolescents with psychiatric disorders for use by Latino families.

"Therapeutic Schools: Affect Management & HIV Prevention" Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Mental Health Type: R01 (MH 066641) Period: 9/1/03 to 6/30/08. $309,850. This collaborative project with UIC will develop and test the efficacy of an affect management intervention as compared to a skills-based intervention and a general health promotion program in improving safer sex behavior among adolescents with psychiatric disorders in intensive treatment settings. The Affect Management intervention from this project will be adapted for juvenile offenders.

"A Multilevel HIV-Prevention Strategy for High-Risk Youth" Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Mental Health Type: U01 (MH066785) Period: 9/30/04 to 7/31/09. $204,506. This collaborative project will develop and test a media intervention, in conjunction with group sessions, in reducing sexual risk behaviors among African-American youth in four cities.

"An Affect Management Intervention for Juvenile Offenders" Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Drug Abuse Type: R21 (DA019245) Period: 10/1/04 to 8/31/06 $185,750 This study will partner with the Juvenile Drug Court to produce a unique intervention that incorporates Affect Management with more traditional skills approaches and to inform the development of a larger study of HIV prevention with drug-abusing juvenile offenders.

"Drug Use and HIV/STI Risk Trajectories among Court-Involved, Non-Incarcerated Youth" Principal Investigator: Marina Tolou-Shams, Ph.D.
Agency: National Institute of Drug Addiction Type: R01DA034538 Period: 7/1/2013-3/31/2018 The goal of this study is to conduct a longitudinal epidemiological assessment of HIV/STI risk, substance use, psychiatric symptoms and recidivism among 400 court-involved, non-incarcerated juveniles in the Rhode Island Family Court.

"Reduce the Risk: An Affect Management Program for HIV Prevention"
Principal Investigator: Wendy Hadley, Ph.D. Agency: National Institute of Mental Health Type: R42 MH087322 Period: 4/01/13-3/31/15 This project will design, develop, and evaluate immersive virtual reality environments for adolescents to provide realistic scenarios with which adolescents can practice managing affect associated with cues to engage in risk behaviors in tandem with an adolescent HIV prevention program.

"Family-Based HIV Prevention: An Interactive DVD" Principal Investigator: Ivan Juzang, Ph.D. Agency: National Institute of Health
Type: R44 MH082103 Period: 04/01/2012-03/31/14 This project will develop and refine an interactive DVD targeting parent-adolescent communication, parental monitoring and reducing sexual risk behavior among urban African-American youth. Role: Co-Investigator

"A Pilot Gaming Adherence Program for Youth Living with HIV"
Principal Investigator: Larry K. Brown, M.D. Agency: NICHD
Type: RO1HD074848 Period: 10/1/2012-6/30/14. This study that utilizes an iPhone app/game to promote healthy decision making and adherence to medication and treatment in youth and young adults living with HIV.

"Community-Based Participatory Research to Develop School-Based HIV Screening" Principal Investigator: Rebecca Swenson, Ph.D. Agency: National Institute of Mental Health Type: R21 MH095626-01A1 Period: 9/15/2012- 7/31/14 The project will use a community-based participatory research (CBPR) approach to identify whether a school-based HIV screening program would be acceptable and feasible to low-income urban adolescents and other key stakeholders in their community (i.e., parents, school nurses, and administrators). Information gained in the project will help inform the development of a sustainable HIV screening program that could be implemented in school settings to increase adolescent HIV testing rates and serostatus awareness.

"Integrating HIV/STI Sexual Risk Reduction into Adolescent Substance Abuse Treatment" Principal Investigator: Milton Wainberg, Ph.D.
Agency: National Institute of Drug Addiction Type: R01 DA026775 Period: 08/01/10-7/31/13 This project will adapt a multi-family group HIV/STI sexual risk reduction intervention using a Community Based Participatory Research model and pilot test it with adolescents (age 13-18) in outpatient treatment for substance use disorders.

"Integrated Mental Health Treatment & HIV Prevention for Court-Involved Youth" Principal Investigator: Larry K. Brown, M.D.
Agency: National Institute of Mental Health Type: R01MH087520 Period: 7/5/2010-4/30/2015 The purpose of this study is to compare the relative efficacy of an integrated mental health treatment and HIV prevention program to standard-of-care mental health treatment for 200 youth receiving mental health evaluations through the RI Family Court, Juvenile Mental Health Clinic.

"Preventing HIV through Affect Management for High-Risk Early Adolescents" Principal Investigator: Christopher Houck, Ph.D.
Agency: National Institute of Nursing Research Type: R01 NR 011906 Period: 08/19/09-6/30/14 This project will test the efficacy of an affect management intervention compared to a general health promotion intervention in delaying onset of sexual activity and reducing sexual risk for young adolescents (12-14) with mental health symptoms in the public school system.

"Training in Child/Adolescent Biobehavioral HIV Research" Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Mental Health Type: T322 MH 07878 Period: 07/01/2013-06/30/2018
This program for postdoctoral psychologists and psychiatrists provides specialized training in Child & Adolescent Biobehavioral HIV research with infected and at-risk populations

"Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Coordinating Center" Principal Investigator: Craig Wilson, M.D.
Agency: National Institute of Child Health and Human Development
Type: 2U01 HD040533 Period: 03/01/11-02/28/16 The Adolescent Medicine Leadership group and the Coordinating Center will continue to provide scientific and administrative leadership for the Adolescent Medicine Trials Network for HIV/AIDS Interventions. Dr. Brown is a member of the Behavioral Leadership Group.

"Lifespan/Tufts/Brown Center for AIDS Research" Principal Investigator: Charles Carpenter, M.D. Agency: National Institute of Allergy and Infectious Diseases Type: P30 AI042853 Period: 07/01/12-6/30/17 This grant supports infrastructure and developmental work related to AIDS at the affiliated institutions. Dr. Brown is the co-Director of the Prevention Core.

Teaching Experience

Dr. Brown is the Program Director a NIMH-funded T-32 posdoctoral program: "Training in Child/Adolescent Biobehavioral HIV Research." It enrolls five fellow in a two-year postdoctoral training position. Predoctoral trainees also participate in a summer research experience. Dr. Brown has been a primary mentor to 7 academic researchers with NIH clinical research training K awards.

Selected Publications

  • Brown, L., Houck, C., Donenberg, G., Lescano, C., Tolou-Shams, M., Mello, J. Affect regulation and HIV risk among youth in therapeutic schools. AIDS and Behavior, 16(8):2272-2278, 2012.(2012)
  • Whiteley, L., Brown, L., Swenson, R., DiClemente, R., Salazar, L., Vanable, P., Carey, M., Valois, R., Romer, D. African American adolescents meeting sex partners online: Closing the digital research divide in STI/HIV. Journal of Primary Prevention, 33:13-18, 2012(2012)
  • Brown, L., Nugent, N., Houck, C., Lescano, C., Whiteley, L., Barker, D., Viau, L., Zlotnick, C. Safe thinking and affect regulation (STAR): HIV prevention in alternative/therapeutic schools, Journal of the American Academy of Child and Adolescent Psychiatry, 50(10):1065-1074, 2011.(2011)
  • Brown, L., Hadley, W., Stewart, A., Lescano, C., Whiteley, L., Donenberg, G., DiClemente, R. & Project STYLE Study Group. Psychiatric disorders and sexual risk among adolescents in mental health treatment. Journal of COnsulting and Clinical Psychology, 78(4):590-597, 2010. PMCID 291194(2010)
  • Brown, L., Puster, K., Vazquez, E., Hunter, H., & Lescano, C.: Screening practices for adolescent dating violence. Journal of Interpersonal Violence, 22:456-464,2007(2007)
  • Lescano, C., Vazquez, B., Litvin, E., & Brown, L.: Condom use with "casual" and "main" partners: What's in a name? Journal of Adolescent Health, 39:443e1-443e7, 2006.(2006)
  • Brown, L.K., Tolou-Shams, M., Lescano, C.M., Houck, C., Zeidman, J., Pugatch, D., Lourie, K., & SHIELD study group: Depressive symptoms as a predictor of sexual risk among African American adolescents and young adults. Journal of Adolescent Health, 39:444e1-444e8, 2006.(2006)
  • Brown, L., Houck, C., Hadley, W., & Lescano, C.: Self-cutting and sexual risk among adolescents in intensive psychiatric treatment. Psychiatric Services, 56(2), 216-219, 2005.(2005)
  • Brown, L. & Lourie, K. Motivational interviewing and the prevention of HIV among adolescents. Adolescents, Alcohol and Substance Abuse: Reaching Teens through Brief Intervention, P. Monti (Ed.) Guilford Press, New York, NY. 244-274, 2001.(2001)
  • Brown, L., Lourie, K., & Pao, M.: Children and adolescents living with HIV: A review. Journal of Child Psychology, Psychiatry and Allied Disciplines, 41:81-96,2000.(2000)
  • Brown, L., Lourie, K., Zlotnick, C., & Cohn, J.: The impact of sexual abuse on the safer sex behavior of adolescents in intensive psychiatric treatment. American Journal of Psychiatry, 157:1413-1415, 2000.(2000)
  • Brown, L., Schultz, J., Parons, J., Butler, R., Forsberg, A., Kocik, S., King, G., Manco-Johnson, M., & Aledort, L.: Sexual Behavior change among HIV infected adolescents. Pediatrics, 106: 22, 2000.(2000)
  • Brown, L., Kessel, S., Lourie, K., Ford, H., & Lipsitt, L.: The influence of sexual abuse on HIV-related attitudes and behaviors in psychiatrically hospitalized adolescents. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 316-322, 1997.(1997)
  • Brown, L., Reynolds, L., & Lourie, K.: A pilot HIV prevention program for psychiatrically hospitalized adolescents. Psychiatric Services, 48: 531-533, 1997.(1997)
  • Brown, L., Danovsky, M., Lourie, K., DiClemente, R., & Ponton, L.: Adolescents with psychiatric disorders and risk of HIV: A review of the literature. Journal of the American Academy of Child and Adolescent Psychiatry, 36: 1609-1617, 1997.(1997)
  • Brown, L., Schultz, J., & Gragg, R.: HIV-infected adolescents with Hemophilia: Adaptation and coping, Pediatrics, 96: 459-463, 1995.(1995)
  • Brown, L., Reynolds, L. and Brenman, A.: Out of focus: Children's conceptions of AIDS. Journal of Health Education,25: 204-209,1994.(1994)
  • DiClemente, R., & Brown, L.: Expanding the role of pediatricians in HIV prevention for adolescents. Clinical Pediatrics, 33, 235-240, 1994.(1994)
  • Brown, L., DiClemente, R., & Beausoleil, N: Comparison of HIV-related knowledge, attitudes, intention, and behaviors among sexually active and abstinent young adolescents. Journal of Adolescent Health, 13: 140-145, 1992.(1992)
  • Brown, L., DiClemente, R., & Park, T.: Predictors of condom use in sexually active adolescents. Journal of Adolescent Health, 13: 651-657, 1992.(1992)
  • Brown L., Barone, V., & Fritz, G.: AIDS education: The Rhode Island experience. Health Education Quarterly, 18: 195-206, 1991.(1991)
  • Brown, L., DiClemente, R., & Reynolds, L.: HIV prevention for adolescents: Utility of the Health Belief Model. AIDS Education and Prevention, 3: 50-59, 1991.(1991)
  • Brown, L., Etemad, J., Brenman, A., & Dwight, S.: Child and adolescent psychiatrists and HIV disease: A survey. Journal of the American Academy of Child and Adolescent Psychiatry, 30: 723-728, 1991.(1991)
  • Brown, L., Fritz, G., & Barone, V.: The impact of AIDS education on junior and senior high school students: A pilot study. Journal of Adolescent Health Care, 10: 386-392, 1989.(1989)
  • Brown, L., & Fritz, G.: Children's knowledge and attitudes about AIDS. Journal of the American Academy of Child and Adolescent Psychiatry, 27: 504-508, 1988.(1988)
  • Brown, L., & Fritz, G.: AIDS education in the schools: Literature review as a guide for curriculum planning. Clinical Pediatrics, 27: 311-316, 1988(1988)