Ondansetron and Naltrexone: Cue Reactivity and Drinking
This project investigates the separate and combined effects of two promising medications on cue-elicited urge to drink alcohol, on acute alcohol consumption, and on the effects of alcohol ingestion. One study will recruit sober alcoholics into a randomized placebo-controlled laboratory study in which people receive 100 mg/day NAL or .5 mg/day OND or both medications or only placebo. The study will investigate separate and combined medication effects on alcohol cue-elicited self-report craving, heart rate, and blood pressure responses to the sight and smell of alcohol cues. The other study recruits current drinkers and investigates the effects of the same combination of medications on reactions to a drinking an alcohol beverage. Both studies will assess early-onset vs. late-onset alcoholism, family history of alcoholism, and several genetic subtypes as predictors of medication effects on people’s responses. Co-investigators are Rosemarie Martin, John McGeary, Robert Miranda, Peter Monti, Robert Swift, Jennifer Tidey.