Research Projects currently underway within the Diagnostic Imaging Department
(alphabetical order by senior investigator)
Chronic effects of smoke inhalation: inspiratory and expiratory HRCT findings
Primary Investigator: Gerald Abbott, M.D.
Sponsor: RIMI Seed Grant
Description: Evaluate Station Nightclub fire victum utilizing HRCT performed during inspir/expir. And correlate to amount of exposure, PFT, and pulmonary history. Activated August 2005.ACRIN - Contemporary Screening for the Detection of Lung Cancer.
Primary Investigator: Gerald Abbott, M.D.
Sponsor: ACRIN
Funding Source: NCI
Description: A multi-center randomized trial of individuals at a high risk of lung cancer to address whether low-dose helical CT can reduce lung cancer specific mortality. 826 patients recruited and in follow-up for 8 years.Accurate Measurement of Right Ventricular Volumes by MRI.
Primary Investigator: Michael Atalay, M.D.
Sponsor: Department Funded
Description: To determine the best clinical method for measuring RV volumes using MRI. Collaborating with the laboratory of Dr. Florence Sheehan at University of Washington, Seattle, where the technique was developed. 25 Patients to be enrolled.Correlation of Cardiac Output with Vascular Attentuation Values on CTPE study
Primary Investigator: Michael Atalay, M.D.
Funding Source: Department Funding
Description: To quantitatively correlate CT attentuation measurements with cardic output as determined by MRI.Myocardial Abnormalities in Sarcoidosis: Assessment Using Magnetic Resonance Imaging and Correlation with Clinical Outcome.
Primary Investigator: Michael Atalay, M.D.
Sponsor: RIMI Seed Grant
Description: To assess the utility of magnetic resonance imaging for prospectively identifying myocardial abnormalities in a small, asymptomatic sarcoidosis population, and determining their clinical significance through outcomes analysis.MR Imaging of Knee Posterior Meniscus Root Tear after Arthroscopic Surgery
Primary Investigator: Jeffrey Brody, M.D.
Funding Source: Department Funding
Description: To describe findings on MR imaging in patients after arthroscopic posterior meniscal root tear repair.Utility of Preoperative FDG-PET/CT and Ferumoxtran-10 MRI Scanning Prior to Primary Chemoradiation Therapy to Detect Retroperitoneal Lymph Node Metastasis in Patients with Locoregionally Advanced (IB2, IIA =4 CM, IIB-IVA) Carcinoma of the Cervix.
Primary Investigator: Jeffrey Brody, M.D.
Sponsor: ACRIN
Description: To evaluate the diagnostic accuracy of preoperative FDG-PET/CT imaging and ferumoxtran-10 (Combidex) MRI scanning in identifying metastases to abdominal (common iliac, para-aortic, and para-caval) lymph nodes in patients with locoregionally advanced cervical carcinoma.Assessment of MR Diffusion Tensor Imaging for distinguising Parkinson's Disease from Other Atypical Parkinsonian Syndromes
Primary Investigator: Jerrold Boxerman, M.D.
Sponsor: Department Funded
Description: To determine whether there are statistically significant differences in the fractional anisotropy (and other diffusion tensor imaging perameters) in key white matter tracts and deep gray structures between patients with Parkinson's disease and atypical parkinsonian sundromes, such as progressive supranuclear palsy, and multiple system atrophy.Comparison study with corresponding blinded image evaluation following a single-intravenous injection of three different doses of Gadobutrol 1.0 molar in patients with known or highly suspected focal blood.
Primary Investigator: Jerrold Boxerman, M.D.
Funding Source: Berlex Labs
Description: A multi-center, double-blind, randomized, controlled parallel group dose comparison study to determine the effective dose of Gaovist in contrast enhanced lesions of the CNS.Diffusion-tensor and perfusion- weighted MRI for Improved detection of Early Cerebrovascular white matter injury in patients with hypertension.
Primary Investigator: Jerrold Boxerman, M.D.
Funding Source: RIMI Seed Grant
Description: To determine the impact of mid-late life hypertension on the microstructural integrity and m icrovascular perfusion in normal appearing white matter.ACRIN Whole Body MRI in the Evaluation of Pediatric Malignancies.
Primary Investigator: John Cassese, M.D.
Sponsor: ACRIN
Funding Source: NCI
Description: To evaluate the diagnostic performance of whole body fast MRI compared to conventional imaging.Utilization of MR Perfusion Imaging as Screening Tool to Assess the Risk of Stroke in Asymptomatic Patients with Sickle Cell Disaease: A Feasibility Study
Primary Investigator: John Cassesse, M.D.
Sponsor: RIMI Seed Grant
Description: To compare the results of both TCD and conventional non-contrast MRI studies to the finidings on MR perfusion imaging in a select group of asymptomatic patients with SS.Pilot Study of FOLFOX6 or Irinotecan with Bevacizumab (Avastin) With Selective Internal Radiation Therapy (SIRT) "FAST" in First Line Treatment of Patients with Unresectable Colorectal Liver Metastases
Primary Investigator: Gregory Dubel, M.D.
Sponsor: Sirtex Medical Ltd.
Description: This is an obervational treatment use protocol that will provide IRB oversight and documentation of the clinical experience of patients undergoing threatment for unresectable liver metastases using resin microspheres concurrent with standard first line chemotherapy and biologic therapy.Radiofrequency Ablation and Brachytherapy in Early Lung Cancer.
Primary Investigator: Damian Dupuy, M.D.
Sponsor: Valleylabs
Funding Source: Valleylabs
Description: Determine the one year local control of combination RF ablation and Brachytherapy in the treatment of inoperable stage IA primary NSCLC.ACRIN - Multicenter Feasibility study of Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma in Cirrhotic Patients.
Primary Investigator: Damian Dupuy, M.D.
Sponsor: ACRIN
Funding Source: NCI
Description: This protocol is a prospective multi-center feasibility trial of the use of percutaneous RFA to treat HCC in pations with cirrhosis. Approximately 120 participants at 10 sites.Percutaneous US and CT-guided Cryoablation of Painful Metastases Involving Bone: A Feasibility Study.
Primary Investigator: Damian Dupuy, M.D.
Sponsor: Mayo Clinic Rochester
Description: Single arm, multi-center, paired comparisons observational study. 72 participants enrolled at 5 sites.Utility of an Electromagnetic Tracking Device for CT-guided Interventional Procedures
Primary Investigator: Damian Dupuy, M.D.
Sponsor: Veran Medical Technologies, Inc.
Description: To evaluate an imaging guidance system utilizing the VMT ig4 system for biopsy or ablation procedures.Proteomic Analysis of Patients Before and After Thermal Ablation Therapy
Primary Investigator: Damian Dupuy, M.D.
Sponsor: Department Funding
Description: To identify profiles of non-plasma proteins released into blood of cancer patients undergoing thermal ablation.Impact of Preoperative Contrast MR of the Breast in Breast CA Patients
Primary Investigator: Susan Koelliker, M.D.
Description: To evaluate the ability of contrast enhanced breast MR to detect other cancers in either breast.Ultrasound Guided FNA of Axillary Lymph Nodes in patients with Breast Cancer
Primary Investigator: Martha Mainiero, M.D.
Funding Source: Department Funding
Description: To determine the utility and cost-effectiveness of US-guided FNA of axillary lymph nodes in patients with breast cancer as a function of tumor size and lymph node appearance. 90 patients enrolled.Medical Simulation Intervention in the Education of Radiology Residents in Contrast Reaction Management
Primary Investigator: Martha Mainiero, M.D.
Funding Source: Department Funding
Description: To determine whether medical simulation-based intervention improves radiology resident learning of and confidence in management of contrast reactions.PREDICT: Patients with Renal Impairment and Diabetes Undergoing Computed Tomography
Primary Investigator: William Mayo-Smith, M.D.
Sponsor: Bracco
Description: Phase IV, multi-center, randomized, double-blind parallel group. 400 participants enrolled at 25-30 sites.DEPICT (DEtection of Pulmonary Embolism Comparing ISOVUE®-370 and VISIPAQUE™-320 Using 64-Slice Multidetector Computed Tomographic Angiography)
Primary Investigator: William Mayo-Smith, M.D.
Sponsor: BRACCO
Description: To compare the efficacy of ISOVUE and VISIPAQUE in pulmonary MCTA, in terms of CT attenuation values Hounsfield Units (HU), measured at various levels of the pulmonary arteries.Gastric Residence Time of a Placebo Polymer: Preliminary Study
Primary Investigator: Brian Murphy, M.D.
Sponsor: Spherics, Inc.
Description: To determine the gastric residence time of placebo BioGIT formulations in healthy volunteers.Magnetic Resonance Assessment of Right Ventricular Dysfunction in Patients with Known Pulmonary Embolism: Correlation with CTPA Findings and Patient Outcome
Primary Investigator: John Pezzullo, M.D.
Sponsor: RIMI Seed Grant
Description: MR assessment of the right ventricle pressure and function to elucidate the mechanisms of decompensation in acute PE at different clot loads.Assessment of Diffusion Tensor Imaging for the Prediction of Histology and Mode of Intracranial Spread in Adult Patients with Brain Tumors
Primary Investigator: Jeffrey Rogg, M.D.
Funding Source: Department Funding
Description: To refine existing techniques using data obtained with MR diffusion tensor imaging in patients with brain tumors for the prediction of tumor histology.CAPTURE - Post Approval Study of the Guidant Carotid Stent Systems and Embolic Protection Systems
Primary Investigator: Gregory Soares, M.D.
Sponsor: Guidant
Description: Observational trial of ACCULINK carotid stent and ACCUNET carotid protection-systems.A Multi-Institutional Analysis of Clinical and Ultrasound Features of Benign and Malignant Thyroid Nodules
Primary Investigator: Rahul Somvanshi, M.D.
Sponsor: Washington University School of Medicine
Description: To establish a prospective, multi-intstitutional database that will allow for reporducible risk categorization of thyroid nodules based on sonographic and clinical factors.ACRIN - PET Pre/Post Treatment Assessment of Locally Advanced NSCLCA
Primary Investigator: Don Yoo, M.D.
Sponsor: ACRIN
Funding Source: NCI
Description: To evaluate the ability of PET-SUV to predict long term survival.
