Sarah Delaney
Assistant Professor:
Chemistry
Phone: (401) 863-3590
Sarah_Delaney@brown.edu
The research in my laboratory aims to understand the biological consequences of DNA damage. Using the tools of chemistry and biology we probe the effects of DNA modification at the molecular level. We are particularly interested in the role of oxidative DNA damage and its contributions to cancer and neurological disorders such as Huntington's disease.
Biography
B.A. in Chemistry, Middlebury College (Advisor: Sunhee Choi)
Ph.D. in Chemistry, Caltech (Advisor: Jacqueline K. Barton)
Postdoctoral Fellow in Biological Engineering, MIT (Advisor: John M. Essigmann)
Interests
The Delaney lab aims to unravel the connections between DNA damage and disease. Using the methods and tools of biochemistry, synthetic chemistry, molecular biology, toxicology and biophysics we probe the effects of DNA damage from the molecular to the cellular level. As a chemistry lab, we exploit our abilities to synthesize DNA lesions and study their properties within well-defined systems. For instance, we are interested in determining the type and frequency of mutations caused by individual DNA lesions. Another focus of the lab is on understanding how chemically modifying DNA affects its overall structure and how those modifications influence the inheritance of genetic information.
Degrees
PhD
Awards
2009 ADVANCE Career Development Award
2008 Richard B. Salomon Research Award
2004-2007 Damon Runyon Postdoctoral Fellowship
2003 Ralph M. Parsons Graduate Fellowship
2002 Dow Chemical Company Travel Grant
1999 ACS Award for Outstanding College Senior
1997 Barry M. Goldwater Scholar
Affiliations
American Chemical Society
