C. Agarwal, Ph.D.
Professor (Research), Department
of Molecular Pharmacology, Physiology, and Biotechnology
Division of Biology and Medicine
Providence, RI 02912
Fax: (401) 863-1595
Dr. Agarwal has
been doing research at Brown University since September, 1968.
His research interests include the development of antithrombotic
and cardiovascular drugs from medicinal plants, marine organisms,
and synthetic sources.
Society of Thrombosis and Haemostasis
Society of Pharmacology and Experimental Therapeutics
Heart Association (Council on Thrombosis)
Herb Research Foundation
Academy of Neuroscience
active principles with strong antithrombotic activities
in garlic and Chinese mushroom (black-tree fungus,
project for Phase II antithrombotic drug testing for an
international pharmaceutical company for biochemical and
pharmacological effects on platelets.
a new biochemical action explaining the mechanism of
action for a widely used anti-stroke drug.
antithrombotic activity of a commercially used
- Worked out
a definitive mechanism of action for a widely used
vasodilatory and antiplatelet drug.
a unique biochemical property of forskolin, a diterpene
from an Indian medicinal plant, Coleus
forskohlii. This unique biochemical
property suggests that forskolin could be a potentially
important drug for thromboembolic disorders,
hypertension, and cancer.
U.S. Patent on "Treatment of Cancer Metastasis by
FORSKOLIN and its Derivatives."
that a low-dose aspirin (81 mg of baby aspirin) when
administered sublingually, may prevent complications
caused by acute myocardial infarction. Our studies
suggest this low-dosage of aspirin may be taken every
fifth day sublingually by patients with coronary artery
disease to prevent heart attack and stroke.
a clinical study (Co-Director) on "Cardiovascular
Protective Effects of Garlic" in hyperlipidemic
papers from several National and International Journals
- Member of
the Study Section, National American Heart Association
- Member of
American Cancer Society Institutional Grant Award
Committee (1985 - 1994)
Science Award Committee, and member of executive
committee, Association of Scientists of Indian Origin in
- Member of
Executive Committee, South Asian Society on
Atherosclerosis & Thrombosis, 1993-1996
Award, sponsored jointly by the Government of India and
United Nations in the TOKTEN program (1994-1995)
(Selected from 61 full publications and 76 Abstracts)
A Potential Antimetastatic Agent.
K.C. Agarwal and R.E. Parks, Jr.
Int. J. Cancer 32, 801-804 (1983.)
(Allium Sativum): Antithrmobotic Actions
Drug News and Perspectives 5, 592-594, (1992.)
- Effect of
Dipyridamole Therapy on Myocardial Ischemia in Patients
with Stable Angina Pectoris Receiving Concurrent
M.M. Barbour, C.E. Garber, K.C. Agarwal, R.
Malhotra, and G.V. Heller
Am. J. Cardiol. 69, 449-452, (1992.)
Factor (PAF)-Induced Platelet Aggregation: Modulation by
Plasma Adenosine and Methylxanthines.
K.C. Agarwal, E. Clarke, S. Rounds, R.E. Parks,
Jr., and Huzoor-Akbar
Biochem. Pharmacol., 48, 1909-1916 (1994.)
Aggregation and Inhibitors.
In: Principles of Cell Adhesion, (M. Steiner and
P.D. Richardson, eds.), CRC Press, Boca Raton, FL,
Actions of Garlic Constituents.
Medicinal Research Reviews, 16, 111-124 (1996.)
and Regulation of Platelet Activation.
In: Purines and Myocardial Protection
(A.S. Abd-Elfattah and A.S. Wechsler, eds.), Kluwer
Academics, 409-418 (1996.)
Effects of a Low-Dose Aspirin Following Sublingual
A. Garg, R.P. Miech, and K.C. Agarwal
FASEB J. 10 (1996.)
Contact Dr. Agarwal at email@example.com