Robert M. Dowben

M.D., University of Chicago, 1949
Adjunct Professor of Physiology
Department of Molecular Pharmacology, Physiology
& Biotechnology
323 Biomed Center
Tel. (401) 863-7369

Research Summary

Robert Dowben is Adjunct Professor of Physiolog:y, Brown University. A.B., Haverford College, 1946; M.S. (Biochemistry) 1947, and M.D., University of Chicago, 1949. Dr. Dowben has had faculty appointments at the University of Pennsylvania Medical S! chool, Northwestern University School of Medicine, jointly at Massachusetts Institute of Technology and Harvard Medical School, University of Texas Southwestern Medical Center Dallas, and Brown University. He is the author of more than 150 scientific! articles and four books dealing mainly with cell membrane proteins, muscle proteins and muscle diseases. His most recent research deals with the hydrodynamic properties and protein interactions usiinig fluorescence resonance energy transfer and fluo! rescence polarization techniques. Dr. Dowben is an avid reader and enjoys music, sailing and helping his wife with gardening.


Representative Publications:

Herbert, T. J., Weltman, J. K., Frackelton, A. R.,Jr., and Dowben, R. M.: Dielectric dispersion of actin. J. Meehan. Cell Motil., 4 ,79-85, 1977.

Wegener, W. A., Koester, V. J. and Dowben, R. M.: A general ellipsoid cannot always serve as a model for the rotational diffusion properties of arbitrarily shaped rigid molecules. Proc. Natl. Acad. Sci., 76, 6356-6360, 1979.

Lin, T-I. and Dowben, R. M.: Studies on the spatial arrangement of muscle thin filament proteins using fluorescence energy transfer. J. Biol. Chem., 258, 5142-5150, 1983.

Bunting, J. R., Phan, T. V., Kamali, E. and Dowben, R. M.: Fluorescent cationic probes of' mitochondria: Metrics and mechanism of interaction. Biophys. J., 56, 979-993, 1989.

Lin, T.-I, Kim, M. and Dowben, R. M.: Accessibility of thiols in actin -- A kinetic study with fluorescent maleimide probes. In, Sperelakis, N. and Wood, J.D., eds., Frontiers in Smooth Muscle Research, Prog. Clin. Biol. Res., 327, 771-778,! 1990.

Lin, Tsung-I, Mayadevi, M., and Dowben, R. M. Modulation of troponin-C binding to troponin-T by Ca2+, probed by fluorescence. J. Chinese Chem. Soc. 40, 607-619, 1993.