Welcome to the Basu Lab...
Research in the group includes –
glycochemistry and glycobiology
synthesis and application of novel polymers and nanomaterials
development of new sensors and diagnostic agents.
If you are interested in joining the research group as an undergraduate student, prospective graduate student, or prospective post-doctoral associate, click here.
Recent and current projects include –
1) studies of carbohydrate-carbohydrate interactions. – Nicole Seah; Jingsha Zhao
Related publications – Rai 2003, Rai 2004, Rai 2005, Santacroce 2003, Santacroce 2004, Seah 2008
2) chemical biology of pollen tube growth – Shannon Stone, Jason Becker, in collaboration with Prof. Mark Johnson, David Kern, Laurel Wright
3) preparation and evaluation of new nanomaterials and nanoscale polymer capsules – Xiang Liu, Shane Mulligan
Related publications – Liu 2006, Limapichat 2008, Liu 2008
4) diagnostic sensors for cell surface glycosylation – in collaboration with Prof. Matthew Zimmt, Yaqi Wang, Prof. Douglas Gnepp (Brown Medical School)
Related publications – Mulla 2003, Rangin 2004
5) oligonucleotide modifications for DNA sequencing – Yogeshkumar Munot, in collaboration with John Oliver at NABSys
Nanopore based DNA sequencing coupled with sequencing by hybridization algorithms offer the potential for rapid and cheap genome sequencing. We are collaborating with NABSys to develop probes to faciltate nanopore based sequencing.
6) glycoconjugates as inhibitors
Related publications – Rossi 2006
15. "Cross-linked polynorbornene-coated gold nanoparticles – Dependence
of particle stability on cross-linking position and cross-linker structure"
X. Liu and A. Basu Langmuir, Accepted for publication.
14. "Carbohydrate-carbohydrate interactions" N. Seah and A.
Basu, Encylopedia of Chemical Biology, J. Wiley & Sons. (In press,
doi: 10.1002/9780470048672.wecb199).
13. "Reagentless functionalization of gold nanoparticles via a 3+2 Huisgen
cycloaddition." W. Limapichat and A. Basu, J. Colloid Interface Sci. 2008,
318, 140-144.
12. "Model Systems." Basu, A. and Schneider, J. Curr. Opin.
Chem. Biol. 2006, 10, 527–528.
11. "Olefin Metathesis on Nanostructures." Liu, X. and Basu,
A. J. Organomet. Chem. 2006, 691, 5148-5154. (Invited Submission, Special
Issue on Alkene Metathesis)
10. "Two Polymerizable Derivatives of 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic
acid)" J. Fei, A. Basu, F. Xue, G. T. R. Palmore Org. Lett. 2006;
8, 3-6.
9. "Glycosidase Inhibition by 1-Glycosyl-4-Phenyl Triazoles" L.
L. Rossi and A. Basu. Bioorg. Med. Chem. Lett. 2005, 15, 3596-3599.
8. "Synthesis of the glycosphingolipid β-galactosyl ceramide
and analogs via olefin cross metathesis." A. N. Rai and A. Basu. J.
Org. Chem. 2005, 70, 8228-8230.
7. "Studies of the Carbohydrate-Carbohydrate Interaction Between
Lactose and GM3 using Langmuir Monolayers and Glycolipid Micelles" P.
V. Santacroce and A. Basu. Glycoconjugate J. 2004. 21, 89-95. (Invited
Submission, Special Issue on Carbohydrate-Carbohydrate Interactions)
6. "Sphingolipid synthesis via olefin cross metathesis: Preparation
of a differentially protected building block and application to the synthesis
of D-erythro-ceramide." A. N. Rai and A. Basu Org Lett. 2004, 6,
2861-2863.
5. "Lipopolysaccharide identification with functionalized polydiacetylene
liposome sensors." M. Rangin and A. Basu. J. Am. Chem. Soc. 2004,
126, 5038-5039.
4. "3-Methoxycarbonyl-5-nitrophenyl boronic acid: High affinity
diol recognition at neutral pH." H. R. Mulla, N. J. Agard and A. Basu
Bioorg. Med. Chem. Lett. 2004, 14, 25-27.
3. "A Rapid and Efficient Method for para-Methoxybenzyl Ether Formation
with Lanthanum Triflate." A. N. Rai and A. Basu. Tetrahedron. Lett.
2003, 44, 2267-2269.
2. "Probing Specificity in Carbohydrate-Carbohydrate Interactions
with Micelles and Langmuir Monolayers." P. V. Santacroce and A.
Basu. Angew. Chem. Int. Ed. Engl. 2003, 42, 95-98.
1. "Configurational Stability and Stereoinformation Transfer in
the Reactions of Enantioenriched Organolithium Reagents." A. Basu and
S. Thayumanavan Angew. Chem. Int. Ed. Engl. 2002, 41, 716-738.
Contact Information
Department of Chemistry
Brown University Box H
324 Brook Street
Providence, RI 02912
Tel 401 863 9897
Fax 253 540 0698
abasu[at]brown.edu