Research Areas

Biology of Aging/Cell Cycle Regulation/Cancer

Prof. John Sedivy, Molecular Biology, Cell Biology and Biochemistry

John Sedivy is recognized for his efforts in mammalian genetics, having developed and pioneered methods for gene targeting of somatic cells. In 1995 his laboratory isolated the first viable gene knockout of the Myc oncogene, and in 1997 the first homozygous gene knockout in a normal human cell. Part of his research program has investigated cell cycle regulation in cancer. Since 1998 his work has focused increasingly on the biology of human aging at the cellular level. His laboratory currently studies how telomere shortening as well as telomere-independent stresses cause cellular senescence.