The Brown University Neurotechnoloy program promotes interdisciplinary research leading to the development of devices to assist the nervous system. Research efforts are aimed at developing microscale implantable sensors for medical applications, devising ‘brain-like’ computing approaches, improving prosthetics, and creating devices that respond directly to brain signals to control computers, robots, or other machines. Such applications could potentially restore mobility and independence to paralyzed patients, amputees, and individuals with other nervous system impairments. They could also allow the remote operation of vehicles or other equipment in hazardous conditions. The realization of such applications require advances in neuroscience, biomechanics, computer science, mathematics, control and information theory, and material sciences/engineering; the multidisciplinary teams formed within the Neurotechnology Program are poised to make such strides by working together at the interfaces among these fields.