Faculty Profile: Kenneth Hugh Mayer, MD

Kenneth Hugh Mayer
Kenneth Hugh Mayer, MD
Adjunct Professor of Medicine and Professor of Epidemiology
Medicine and Epidemiology
Work: 1-401-793-4710
Kenneth H. Mayer has studied the natural history of HIV and the biological and prevention aspects of HIV acquisition and transmission since the start of epidemic. He led research teams that documented the first cases of HIV in New England. He studied the heterosexual spread of HIV and viral HIV expression in the male and female genital tracts. He led prevention research studies, including behavioral interventions, microbicides, and vaccine trials. He is also the principal investigator of an international training grant funded by the Fogarty International Center of the National Institutes of Health (NIH).

Biography

Professor of Medicine and Community Health, Brown; Director, Brown AIDS Program; Attending ID Physician, Miriam Hospital; Adjunct Professor, Harvard University's School of Public Health; Medical Research Director, Fenway Community Health. Conducted studies of HIV's natural history and transmission. One of the first clinical researchers in NE to care for patients living with AIDS. Director, Brown/Tufts/Lifespan Fogarty (NIH) AIDS International Research and Training Program. Has worked increasingly in India. Participant, lecturer and presenter at regional conferences and symposia on biological and behavioral approaches to prevention research and the development of community-based clinical research. Co-edited The Emergence of AIDS: Impact on Immunology, Microbiology, and Public Health, American Public Health Association Press. Has served on Data Safety and Monitoring Board of the NIH's AIDS Clinical Trials Group. Sits on several editorial boards of scientific publications. Has co-authored more than 350 articles, chapters and other publications on AIDS and related infectious disease topics.

Institutions

Mhri

Research Description

Kenneth Mayer has studied the natural history of HIV, as well as the biological and prevention aspects of HIV acquisition and transmission since the start of the epidemic. He has led research teams that have documented the first cases of HIV in New England, studied the heterosexual spread of HIV and viral HIV expression in the male and female genital tracts, and has led prevention research studies, including behavioral interventions as well as microbicide and vaccine trials. He has also been the principal investigator of an international training grant funded by the Fogarty International Center of the National Institutes of Health (NIH), which has led to new collaborations to define the natural history of HIV in India and to develop cost effective monitoring strategies for people living with HIV as they access generic antiretroviral therapy.

Grants and Awards

2001 Dean's Teaching Excellence Award, Brown Medical School, Brown University, Providence, RI
2001 Paul J. Galkin Lecturer for Distinguished Leadership in HIV/AIDS, Brown University, Providence, RI.
2002 Honorary life membership of The Indian Medical Association, Chennai Central Branch, India
2002 Medical Achievement Award, AIDS Project Rhode Island Annual Meeting, Warwick, RI
2003 Listed in: Best Doctors in America 2003-2004
2004 Dean's Teaching Excellence Award, Brown Medical School, Brown University, Providence, RI

Affiliations

HOSPITAL APPOINTMENTS
1980-present Staff Physician and Medical Research Director, Fenway Community Health Center, Boston, MA
1981-present Attending Physician, Beth Israel Hospital, Boston, MA
1984-present Courtesy Staff, Department of Medicine Roger Williams General Hospital, Providence, RI
1986-present Consulting and Attending Staff, Department of Medicine Miriam Hospital, Providence, RI

OTHER APPOINTMENTS
1983-present Consultant to the Massachusetts Department of Health, Division of Communicable and Venereal Diseases
1987-present Faculty Associate, Center for Gerontology and Health Care Research, Brown University
1988-present Medical Advisory Committee, Rhode Island Project AIDS
1990-present American Foundation for AIDS Research, Scientific Advisory Committee
1990-present Visiting Scientist, Massachusetts Institute of Technology Clinical Research Center
1991-present Member, Epidemiology and Technology Transfer Subcommittee of the AIDS Research Review Committee (Study Section), National Institute of Allergy and Infectious Diseases (NIAID)
1991-present International Scientific Committee, 2nd, 3rd, 4th and 5th International Conferences on the Prevention of Infection; (Nice, France 1992, 1994, 1996, 1998)
1991-present National Board, American Foundation for AIDS Research Chair, Treatment Information Services Subcommittee; Co-Chair: Clinical Research Committee.
1991-present Fellow, Wayland Collegium, Brown University
1991-present Center for Alcohol and Addiction Studies, Brown University, Post-doctoral Training Program Faculty
1997-present Clinical Advisory Panel, Cost-Effectiveness of Preventing AIDS Complications (CEPAC), (NIH RO1: K. Freedberg, PI), Boston University School of Medicine/Harvard Medical School.
1998-present AIDS Committee, Infectious Disease Society of America; Steering Committee, HIV Medicine Association
2001 - Board of Directors, New England Chapter, American Academy of HIV Medicine.
2004-5 Planning Committee, 17th National HIV/AIDS Update Conference, American Foundation for AIDS Research (amfAR)
2005 Program Committee, Treatment and Management of HIV Infection in the United States, US Department of Veterans Affairs; Session Chair, Prevention Track.
2005 Science Program Committee, 1st National Conference of AIDS Society of India
2005 International Partnership for Microbicides Scientific Advisory Board
2005 Editorial Board, Journal of LGBT Health Research
2005 Health Action AIDS Advisory Board Executive Committee, Physicians for Human Rights
2005 Program Committee Member, Track C, Microbicides 2006 Conference, Cape Town, South Africa
2005 HIV/AIDS Prevention Science Working Group, Office of AIDS Research, NIH
2006 Biomedical Prevention Track Committee, 4th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention, July 22-25, 2007, Sydney, Australia

ONGOING TEACHING ROLES
1983-present Multiple annual lectures to undergraduates; first and second year Brown University Medical Students on:
1. Pharmacology and Mechanisms of Action of Antibiotics
2. Antibiotic Resistance
3. Epidemiology, Clinical Manifestations, and Treatment of HIV/AIDS
1987-present Doctoral thesis advisor and committee member for six graduate students in either Community Health (Brown), or Epidemiology or Immunology and Infectious Disease (Harvard School of Public Health)
1991-present Director: Medical Student Senior Seminar: Lessons of AIDS, Brown University
1992-present Faculty for University of Rhode Island's Virology course, lecture on "HIV/AIDS"

MEMBERSHIP IN SOCIETIES
1980 American Federation for Clinical Research
American College of Physicians (Fellow, 1985)
American Society for Microbiology
American Public Health Association
1983 Association for Practitioners in Infection Control
American Association for the Advancement of Science
American Venereal Disease Association
1985 Infectious Disease Society of America; AIDS Committee Member (1993-present)
Society for Epidemiological Research
1988 International AIDS Society (IAS)
International Society for Infectious Diseases
1990 International Academy of Sex Research
1991 Society for Hospital Epidemiology
1992 Immunocompromised Host Society
Society of Hospital Epidemiologists of America; AIDS/TB Committee (1993-1996)

Funded Research

ACTIVE: (The Miriam Hospital Site) %FTE

5 H4A-HA00013-03 (Mayer) 07/01/06 - 06/30/07 7%
Health Resources and Services Administration (HRSA) $31,153
New England AIDS Education and Training Center
The major goal of this program is to educate primary care providers about AIDS and HIV infection through didactic courses and clinical supervision in ambulatory settings.

P30 AI42853-05(Carpenter) 09/01/98-06/30/07 5%
National Institutes of Health (NIH) $120,892 (7/01/05-06/30/06)
Center for AIDS Research (CFAR)
Prevention Core
This Center for AIDS Research proposal represents a collaboration between faculty at Brown University and Tufts University. The broad goals of this proposal are 1) to stimulate translational AIDS research with women, minorities, and other under-represented groups; 2) to enhance research in prevention science; 3) to integrate nutritional assessment/intervention and outcomes analysis into clinical research; 4) to encourage multidisciplinary research on the clinical issues surrounding new therapies and the accompanying extended survival of HIV(+) patients; and 5) to explore effective screening, treatment and prevention of viral-induced carcinomas in AIDS patients.

TW00237 (Mayer) 6/01/05 - 5/31/10 15%
Fogarty International Center $637,500 (06/01/06-05/31/07)
AIDS International Research and Training Program
This training grant funds the U.S. and overseas education of clinical, laboratory and behavioral AIDS researchers in the Philippines, Indonesia, India, Bangladesh, and Cambodia. The training activities include tutorials, degree programs, and in-country courses which educate the trainees in current epidemiological, laboratory, and behavioral techniques.

N-00403 (Carpenter) 10/1/2002 - 9/30/2007 3%
Centers for Disease Control and Prevention (CDC) $424,822
Study of the Unnatural History of HIV (SUN)
The major goals of this project are to study the many manifestations, morbidities, and moralities of Human Immunodeficiency Virus (HIV) in women in the post-Highly Active Antiretroviral Therapy (HAART) era (since 1996) and to incorporate HIV-prevention activities into HIV medical care.

1U10 MH61543 (Celentano) 9/1/05 - 8/31/06 5%
National Institute of Mental Health (NIMH) $39,624 (TMH only)
NIMH Collaborative HIV/STD Prevention Trial
K.M. Mayer provides expertise in the area of STD diagnostics.

5 R01 AI 058736-02 (Freedberg) 7/1/04 - 6/30/08 10%
NIH-National Institute of Allergy and Infectious Diseases (NIAID) $180,550 (TMH only)
Optimizing HIV Care in Less Developed Countries
To develop the Global AIDS Policy Model, a comprehensive and flexible state-transition model of the natural history and treatment of HIV disease in less developed countries; to analyze data on HIV natural history, treatment efficacy, costs and quality of life in India; to assess the clinical impact, cost, and cost-effectiveness of different strategies for antiretroviral therapy, opportunistic infection prophylaxis, and tuberculosis preventive theory.

(Mayer) 3/1/06-12/31/06 1%
AIDS Project Rhode Island/ Rhode Island Department of Health $22,770
HIV Prevention/Disease Control Measures Coordination
To do outreach and HIV testing at the largest gay bath house in NE, which is located in Providence; to promote safer sexual practices among at-risk and HIV-infected men who have sex with men in NE.

(Mayer) 4/1/06-3/31/07 1%
Massachusetts Department of Public Health $13,075
STD/HIV Prevention Training Center
To develop a multi-disciplinary program to educate local providers about STD and HIV prevention.

ACTIVE: (Fenway Community Health Site) FTE (%)

1RO1MH68746-01 (Mayer) 08/01/03-7/31/08 14%
NIMH $535,847 (5/1/06-4/30/07)
Enhancing HIV Prevention Among HIV+ MSM in Care
The aims of this project is to develop and test a cost-effective, easy-to-administer, secondary HIV prevention intervention for HIV-infected MSM that can be integrated into an HIV medical care setting through medical social workers. The intervention will include education, motivational and behavioral skills enhancement.

1 U01 AI48040-03 (Mayer) 7/1/06-12/31/06 13.5%
NIAID $419,512
HIV Prevention Trials Unit (HPTU)
This cooperative agreement will fund HIV prevention interventions, including studies of microbicides, STD treatment, antiretroviral use as prophylaxis, and studies to decrease injection drug use and to interrupt perinatal HIV transmission. The HPTU is based at Fenway Community Health and has oversight for sub-sites in Providence, RI as well as in Chennai, India.

1 U01 AI48023-03 (Dolan) 06/01/06-12/31/06 10%
NIAID $292,260
HIV Vaccine Trials Unit (HVTU)
This cooperative agreement (as a subcontract with Harvard Medical School) is a collaboration between Harvard Medical School and Fenway Community Health to develop a preventive HIV vaccine research unit, which will focus on clinical trials.

1R01MH068746-01 (Mayer) 9/01/03-8/31/07 5%
HRSA $300,000 (9/1/05-8/31/06)
Enhancing HIV Prevention Among HIV+ MSM in Primary Care Settings
This study is to develop and test a behavioral intervention for HIV positive men who have sex with men, integrated into treatment at a community health center and delivered by peer interventionists.

1 R01 HD046060-01 8/01/05-7/31/06 2.5%
National Institute of Child Health and Human Development (NICHD) $225,740
Topical Rectal Microbicide Acceptability
This study will look at the tolerability and acceptability of a placebo rectal microbicide product at different volumes. It will also seek to gain information about the psychological, social, and cultural factors associated with anal sex among women.

R01-MH064412 7/1/05-6/30/06 2%
NIMH $29,568
An RCT HIV Prevention Program for Persons with HIV
This is a subcontract from the University Of Minnesota. This project aims to adapt the content of an existing, empirically tested sexual health intervention for MSM of all serostatuses, into a new intervention specifically target to meet the sexual health concerns, needs, and behaviors of HIV+ MSM.

2/1/06 – 7/31/07 3%
NIH/ National Institute on Drug Abuse (NIDA) $267,018
Assessing HIV in Hidden Populations: A Feasibility Study
The goal of this feasibility study is to test components of a method for assessing HIV, illegal or prescribed drugs, sexually transmitted disease, or other infectious disease in two hidden populations; men who 1) Frequent PSEs or 2) are clients of FSWs.

Teaching Experience

ACADEMIC APPOINTMENTS
1987-present Director, Brown University AIDS Program
1993-present Professor of Medicine and Community Health
Brown University School of Medicine
1989-present Adjunct Associate Professor of Epidemiology
University of Massachusetts, Amherst, MA
1994-present Executive Committee, Brown University AIDS International Training Program Grant (Fogarty Center, NIH)
1996-present Fellowship Director; Principal Investigator: Brown University, International Training Grant in AIDS Epidemiology (Fogarty Center, NIH)
1997-present Foreign Studies Fellowship Jury, Brown University School of Medicine
1998-present Executive Committee, Lifespan-Brown-Tufts Center for AIDS Research;
Director, Prevention Science & Education Core
1999-present Executive Committee, Brown University International Health Institute