Faculty Profile: James Arrighi, MD

James Arrighi
James Arrighi, MD
Associate Professor of Medicine
Work: +1 401-444-8041


College: Brown University, 1984
Medical School: Brown University, 1987
Residency (Internal Medicine): Barnes Hospital, Washington University (St. Louis), 1987-1989
Fellowships: National Institutes of Health (Nuclear Cardiology), 1989-1992; Yale University (Cardiology and Nuclear Medicine), 1992-1994

After training in cardiology at NIH and Yale, Dr. Arrighi joined the Yale faculty in 1994. At Yale, his clinical and research activities were focused in nuclear cardiology. In addition, he was involved in the administration of Yale's cardiology fellowship program (from 1996 to 2004, as Associate Director or Program Director). In 2004, Dr. Arrighi joined the Brown faculty, to become the Director of Nuclear Cardiology at Rhode Island Hospital and Program Director of the fellowship in Cardiology.

Dr. Arrighi is active in many professional organizations, including the American Society of Nuclear Cardiology (Board of Directors; Education Committee), the Certification Board of Nuclear Cardiology (Vice President; Board of Directors), the Journal of Nuclear Cardiology (Editorial Board), and the American College of Cardiology (Training and Workforce Committee. He has a particular interest in medical education, and has been actively involved in the education of students, residents, and fellows throughout his career. Dr. Arrighi also currently serves on American Council for Graduate Medical Education's Residency Review Committee for Internal Medicine.

Dr. Arrighi is the Director, Nuclear Cardiology, Rhode Island Hospital and Program Director, Cardiology Fellowship, Brown University.



Research Description

I am interested in the assessment of myocardial perfusion and metabolism with noninvasive techniques using radioactive tracers and other new imaging modalities. These techniques include positron emission tomography (PET), single photon emission computed tomography (SPECT), and CT to investigate cardiovascular pathophysiology. Specific interests include: 1) the assessment of cardiac function and perfusion in coronary artery disease; 2) refining the application of current methods of diagnosis and evaluation of coronary disease, including neuronal imaging in heart failure; 3) potential applications for metabolic FDG imaging of ischemia and vascular disease; 4) refining techniques for the assessment of myocardial viability. The nuclear cardiology section is involved in multicenter trials, and currently in the process of developing other protocols as above.


Fellow, American College of Cardiology
Fellow and Board of Directors, American Society of Nuclear Cardiology
Member, Accreditation Council for Graduate Medical Education Residency Review Commmittee (Internal Medicine)
Vice President, Certification Board of Nuclear Cardiology

Teaching Experience

Program Director, Cardiology Fellowship, Rhode Island Hospital and Brown Medical School

Selected Publications

  • Russell RR, Arrighi JA, Lui Y. Nuclear Cardiac Imaging. In: Lui Y, Wackers FJT. Cardiovascular Imaging. London: Manson Publishing; 2010:44-79 (2010)
  • Russell RR, Abbott BA, Arrighi JA, et al. Highlights of the 2008 scientific sessions of the American Society of Nuclear Cardiology. J Nucl Cardiol 2009;16:440-6 (2009)
  • Arrighi JA. Integrated imaging of cardiac anatomy, physiology, and viability. Current Cardiology Reports 2009;11:125-132 (2009)
  • Arrighi JA, Abbott BG, Wackers FJT. Planar and SPECT equilibrium radionuclide angiography. In: Heller GH, Hendel RC, Mann A. Nuclear Cardiology: Technical Applications. New York: McGraw-Hill;2009:301-314 (2009)
  • Arrighi JA. ECG-gated SPECT imaging. In: Heller GH, Hendel RC, Mann A. Nuclear Cardiology: Technical Applications. New York: McGraw-Hill;2009:289-300 (2009)
  • Giannotti TE, McDonnell J, Arrighi JA, Foody JM. Hospital payment monitoring program: The Rhode Island Experience. Reducing admission denials through the promotion of hospital observation status. Medicine and Health (Rhode Island) 2008;91:28-32 (2008)
  • Bax JJ, Kraft O, Buxton AE, Fjeld JG, Parizek P, Agostini D, Knuuti J, Flotats A, Arrighi J, Muxi A, Alibelli M-J, Banerjee G, Jacobson AF. 123I-mIBG Scintigraphy to predict inducibility of ventricular arrhythmias on cardiac electrophysiology testing. A prospective pilot study. Circ Cardiovasc Imaging. 2008;1:131-140 (2008)
  • Cerqueira MD, Arrighi JA, Geiser EA. Physician certification in cardiology imaging: Rationale, process, and benefits. J Am Coll Cardiol Img 2008;1:801-808 (2008)
  • Abbott BG, Liu Yi-Hwa, Arrighi JA. F-18 fluorodeoxyglucose as a memory marker of transient myocardial ischemia. Nucl Med Commun 2007;28:89-94 (2007)
  • Vashist A, Arrighi JA, Soufer R. Mechanistic and methodologic considerations for the imaging of mental stress ischemia. In: Zaret BL, Beller GA. Clinical Nuclear Cardiology. Philadelphia:Elsevier; 2005. (2005)
  • Arrighi JA, Burg M, Cohen IS, Soufer R. Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease. J Nucl Cardiol 2003;10:267-74. (2003)
  • Soufer R, Arrighi JA, Burg M. Brain, behavior, mental stress and the neurocardiac interaction. J Nucl Cardiol 2002;9:650-62. (2002)
  • Arrighi JA. F-18 fluorodeoxyglucose imaging in myocardial ischemia: beyond myocardial viability. J Nucl Cardiol 2001;8:417-420. (2001)
  • Arrighi JA, Burg M, Cohen IS, Kao AH, Pfau S, Caulin-Glaser T, Zaret BL, Soufer R. Quantitative myocardial blood flow response during mental stress in patients with angiographically-documented coronary artery disease. Lancet 2000;356:310-311. (2000)