Institutions

Selected Publications

• Sean F. Monaghan, Rajan K. Thakkar, Daithi S. Heffernan, Xin Huang, Chun-Shiang Chung, Joanne Lomas-Neira, William G. Cioffi, Alfred Ayala. Mechanisms of Indirect Acute Lung Injury: A Novel Role for the Coinhibitory Receptor, Programmed Death-1. Ann Surg. 2012; 255(1): 158-164. (2012)
• Caroline Guignant, Alain Lepape, Xin Huang, Hakim Kherouf, Laure Denis, Françoise Poitevin, Christophe Malcus, Aurélie Chéron, Bernard Allaouchiche, François Gueyffier, Alfred Ayala, Guillaume Monneret and Fabienne Venet. Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit Care. 2011; 15(2): R99. (2011)
• Fabienne Venet, Xin Huang, Chun-shiang Chung, Yaping Chen, Alfred Ayala. Plasmacytoid Dendritic Cells Control Lung Inflammation and Monocyte Recruitment in Indirect Acute Lung Injury in Mice. Am J Pathol. 2010; 176(2): 764-773. (2010)
• Caroline K. Hu, Fabienne Venet, David S. Heffernan, Yvonne L. Wang, Brian Horner, Xin Huang, Chun-shiang Chung, Stephen S. Gregory, Alfred Ayala. The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock. J Immunol. 2009 Feb 15;182(4):2467-2475. (2009)
• Fabienne Venet, Chun-shiang Chung, Xin Huang, Joanne Lomas-Neira, Yaping Chen, Alfred Ayala. Lymphocytes in the Development of Lung Inflammation: A Role for Regulatory CD4+ T Cells in Indirect Pulmonary Lung Injury. J Immunol. 2009; 183(5): 3472-3480. (2009)
• Xin Huang, Fabienne Venet, Yvonne L. Wang, Alain Lepape, Zhenglong Yuan, Yaping Chen, Ryan Swan, Hakim kherouf, Guillaume Monneret, Chun-shiang Chung, Alfred Ayala. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci U S A. 2009; 106(15): 6303-6308. (2009)
• Nicholas C. Wisnoski, Chun-Shiang Chung. Yaping Chen, Xin Huang, Alfred Ayala. The contribution of CD4+CD25+ T-regulatory cells to immune suppression in sepsis. Shock. 2007; 27(3): 251-257. (2007)