Faculty Profile: Kevin Charpentier, MD

Kevin Charpentier, MD
Assistant Professor of Surgery
Bio Med Surgery
Work: +1 401-444-5285
Irreversible electroporation (IRE) is a novel, non-thermal form of tissue ablation that uses short pulses of high frequency electrical energy to kill target tissue. We are studying the ability of IRE to treat tumors of the liver, bile duct and pancreas that are not amenable to surgical removal.

We are also studying novel chemotherapy regimens for the treatment of pancreas cancer,as well as, primary liver and metastatic liver cancer.

Biography

Dr. Charpentier is a general surgeon with expertise in surgery of the liver, bile ducts and pancreas. He completed a liver, pancreas and kidney transplant fellowship at the University of Washington in 2003 before joining the faculty at the University of Connecticut where he opened and directed the Pancreas Transplant Program. He went on to obtain additional training in laparoscopic liver surgery before being recruited to Brown University and University Surgical Associates in 2006.

Dr. Charpentier has a busy clinical practice treating patients with surgical problems of the liver, bile ducts and pancreas. His research focuses on improving outcomes for patients with cancer of the liver, pancreas and bile ducts. Currently, his funded research focuses on exploring novel techniques for tumor ablation in the liver and pancreas, as well as, developing novel chemotherapy regimens for patients with pancreas and liver cancer. Dr. Charpentier has several publications and has lectured extensively in his field of interest.

Research Description

Irreversible electroporation (IRE) is a novel, non-thermal form of tissue ablation that uses short pulses of high frequency electrical energy to kill target tissue. We are studying the ability of IRE to treat tumors of the liver, bile duct and pancreas that are not amenable to surgical removal.

We are also studying novel chemotherapy regimens for the treatment of pancreas cancer,as well as, primary liver and metastatic liver cancer.

Grants and Awards

1992 Outstanding Achievement in Academics in Excellence in Research
Award, Syracuse University
1993 Hartford Foundation/American Federation for Aging Research
Scholarship
1997 Resident of the Year, Hospital of St. Raphael
1998 Resident of the Year, Hospital of St. Raphael
1999 Resident Leadership Award, Hospital of St. Raphael
2000 Resident of the Year, Hospital of St. Raphael
2000 Medical Staff President's Award for Excellence in Academic
Performance and Scholastic Achievement, Hospital of St. Raphael
2001 Resident of the Year, Hospital of St. Raphael
2003 Henry N. Harkins Award, Washington State Chapter of the
American College of Surgeons
2009 Dean's Excellence in Teaching Award, Warren Alpert Medical
School of Brown University
2010 Outstanding Teaching Faculty Award, Department of Surgery,
Warren Alpert Medical School, Brown University
2011 Dean's Excellence in Teaching Award, Warren Alpert Medical
School of Brown University

Affiliations

2002-present Tufts University School of Medicine, Alumni Association
2002-present Henry N. Harkins Surgical Society
2003-present American College of Surgeons, Fellow
2005-present International Liver Transplantation Society
2005-present American Society of Transplant Surgeons
2005-present International Hepato-Pancreato-Biliary Association
2008-present American Hepato-Pancreato-Biliary Association
2008-present New England Surgical Society
2009-present Society for Surgical Oncology

Funded Research

Oct. 2012 Single Agent Adjuvant Aflibercept For Patients with Resected or Ablated Metastatic Colorectal Cancer: A Randomized Phase II Study
$795,000, Sanofi
Co- principal investigator

Oct. 2012 FOLFOX-Abraxane (A) For Pancreatic Cancer: A Brown University Oncology Research Group Study
$15,000, Philanthropy
Co- principal investigator

Sept. 2012 Microbiomes in Human Pancreatic Cancer
NIH grant submitted
Co-investigator

Jan. 2010 CMTT# 0182-09. Ablation followed by resection in liver: A pilot study of the MedWaves microwave system
$25,000, Medwaves, Inc.
Co- principal investigator

Feb. 2009 CMTT# 0015-09. A Pilot Study of Irreversible Electroporation (IRE) of the Liver and Liver Hilum in the Porcine Model
$38,000, Angiodynamics, Inc.
Co- principal investigator

Feb. 2009 CMTT# 0016-09. A Pilot Study of Irreversible Electroporation (IRE) of the pancreatic head in the Porcine Model.
$25,000 Departments of Surgery and Radiology, Rhode Island Hospital, Providence, RI
Co- principal investigator

Teaching Experience

Warren Alpert Medical School at Brown University, Surgical Clerkship 2007-present
Evaluation of the Jaundice Patient

Department of Surgery/Rhode Island Hospital 2007-present
Topics include metastatic colorectal cancer, primary liver cancer, pancreatic cystic neoplasms, pancreatic cancer, pancreatic pseudocysts, complex biliary disorders, portal hypertension

GI Fellows lecture series 2008-present.
Topics include metastatic colorectal cancer, primary liver cancer, pancreatic cystic neoplasms, pancreatic cancer, pancreatic pseudocysts, complex biliary disorders

Selected Publications

  • 21. Sibulesky L, Charpentier K, Gohh RY, Morrissey PE. Kidney Transplantation from Donors with Severe Disseminated Intravascular Coagulation. International Scholarly Research Network (ISRN) – Transplantation, Accepted 1/2013. (2013)
  • 20. Ratanaprasatporn L, Dupuy D, Resnick M, Lu S, Charpentier KP. Intra-Operative Microwave Ablation of Liver Malignancies with Tumor Permittivity Feedback Control: A Prospective Ablate and Resect Study. HPB accepted 1/2013. (2013)
  • 19. Safran H, Charpentier KP, Kaubisch A, Dubel G, Perez K, Faricy-Anderson K, Miner T, Eng Y, Victor J, Plette A, Espat J, Bakalarski P, Wingate P, Mantripragada K, Berz D, Luppe D, Martel D, Rosati K, Santiago A and Isdale D. Lenalidomide for Second-Line Treatment of Advanced Hepatocellular Cancer: A Brown University Oncology Group Phase II Study. J Clin Oncol accepted for publication 11/2012. (2012)
  • 18. Charpentier, KP. Irreversible electroporation for the ablation of liver tumors: Are we there yet? Arch Surg. Accepted for publication 5/2012. (2012)
  • 17. Shimoda M, Tomimaru Y, Charpentier KP, Safran H,Carlson RI, Wands JR. Tumor progression-related transmembrane protein aspartate b-hydroxylase is a target for immunotherapy of hepatocellular carcinoma. J Hepatol 2012;56(5):1129-35. (2012)
  • 15. Charpentier KP, Wolf F, Resnick M, Noble L, Winn B, Dupuy D. Irreversible electroporation of the liver and liver hilum in swine. HPB 2011;13:168-173. (2011)
  • 14. Safran H, Miner T, Bahary N, Whiting S, Lopez C, Sun W, Charpentier K, Shipley J, Anderson E, McNulty B, Schumacher A, Clark A, Vakharia J, Kennedy T. Lapatinib and Gemcitabine for metastatic pancreatic cancer: A phase II study. Am J Clin Oncol 2011;34(1):50-52. (2011)
  • 16. Miner TJ, Cohen J, Charpentier KP, McPhillips J, Marvell L, Cioffi W. The Palliative Triangle: Better Patient Selection Improves Outcomes Following Palliative Operations. Arch Surg 2011; 146(5):517-23. (2011)
  • 13. Jackson KL, Charpentier KP. Quantitative banding for steal syndrome secondary to arteriovenous fistulae. Ann R Coll Surg Engl 2010; 92:534. (2010)
  • 12. Thomay A, Charpentier KP. Optimizing resection for "responding" hepatic metastases after neoadjuvant chemotherapy. J Surg Oncol 2010;102:1002-8. (2010)
  • 11. Charpentier KP, Wolf F, Resnick M, Noble L, Winn B, Dupuy D. Irreversible electroporation of the pancreas in swine: a pilot study. HPB 2010;12(5):348-51. (2010)
  • 10. Yango A, Gohh R, Fischer S, Morrissey P, Charpentier K, Monaco A. The Utility of 6 Month Protocol Renal Biopsy under Modern Immunosuppression. Clin Nephrol 2008;70(6):490-5. (2008)
  • 9. Charpentier KP, Cheah YL, Machan JT, Miner T, Morrissey P, Monaco A. Intention to treat survival following liver transplantation for hepatocellular carcinoma within a donor service area. HPB 2008;10: 412-15. (2008)
  • 8. Charpentier KP, Mavanur A. Removing patients from the liver transplant waitlist: a survey of United States liver transplant programs. Liver Transpl 2008;14:303-8. (2008)
  • 7. Ojo P, Ranga KV, Brown M, Hull D, Charpentier KP. Transplantation of a unilateral fused kidney with inferior ectopia: revascularization utilizing donor aorta and vena cava. Conn Med 2008;72(10):585-8. (2008)
  • 6. Friedrich J, Charpentier KP, Marsh CL, Bakthavatsalam R, Levy A, Kuhr CS. Outcomes with the selective use of enteric exocrine drainage in pancreas transplantation. Transplant Proc. 2004;36:3101-04. (2004)
  • 5. Charpentier KP, Brentnall TA, Bronner MP, Byrd D, Marsh C. A new indication for pancreas transplantation: high-grade pancreatic dysplasia. Clin Transplant. 2004 Feb;18(1):105-7. (2004)
  • 4. Martay K, Dembo G, Vater Y, Charpentier KP, Levy A, Bakthavatsalam, R Freund PR. Unexpected surgical difficulties leading to hemorrhage and gas embolus during laparoscopic donor nephrectomy: a case report. Can J Anaesth. 2003 Nov;50(9):891-4. (2003)
  • 3. Black PC, Charpentier, KP, Bakthavatsalam R, Marsh C, Porter J. Hand-Assisted, laparoscopic right donor nephrectomy in a patient with situs inversus. Transplantation. 2003 Nov 27;76(10):1530. (2003)
  • 2. Charpentier KP, Welch H. Pseudoaneurysm of the superior mesenteric artery secondary to ergot therapy: a case report. Vascular Surgery 1999; 33(3):335-39. (1999)
  • 1. Charpentier KP, Von Moltke LL, Poku JW, Haramatz JS, Shader RI, Greenblatt DJ. Alprazolam hydroxylation by mouse liver microsomes in vitro: the effect of age and phenobarbital induction. Biopharmaceutics and Drug Disposition 1997; 18(2):139-149. (1997)