Faculty Profile: Frank Sellke, BA, MD, MA

Frank Sellke
Frank Sellke, BA, MD, MA
Karlson and Karlson Professor of Cardiothoracic Surgery
Surgery
Work: 1-401-444-2732
Dr Sellke investigates neurologic, behavioral, and other clinical outcomes during and after cardiac surgery. His interests focus on genomic and proteomic predictors of outcomes, and in particular the influence of inflammation and blood transfusion. Dr Sellke's basic scientific research focuses on the regulation of the microcirculation in health and disease, collateral vessel formation and its regulation, the use of angiogenic growth factors and cell therapy to increase perfusion and function of ischemic tissue and ischemic injury during heart surgery. His research is funded in large part by several grants from the National Institutes of Health.

Biography

Dr Sellke is the Karl Karlson and Gloria Karlson Professor and Chief of Cardiothoracic Surgery at Brown Medical School and the Lifespan Hospitals. Dr Sellke is a native of Indiana and graduated from Wabash College and Indiana University School of Medicine. He is a noted clinical cardiothoracic surgeon, researcher, and author. Dr Sellke was the Chief of Cardiothoracic Surgery at Beth Israel Deaconess Medical Center and the Johnson and Johnson Professor of Surgery at Harvard Medical School prior to moving to Brown. His research interests include the regulation of the microcirculation in health and disease, ischemic injury and inflammation during cardiac surgery, collateral vascular formation and the use of growth factors and cell therapy to increase blood flow to ischemic tissue. Dr. Sellke serves as Associate Editor for the Journal of Thoracic and Cardiovascular Surgery, and is on the editorial board of the Journal of Surgical Research, Shock, and the Journal of Cardiac Surgery. He is the Editor of the of the textbooks, Sabiston and Spencers' Surgery of the Chest and the Atlas of Cardiac Surgical Techniques. Dr. Sellke is the author of more than 280 peer-reviewed journal articles, as well as numerous book chapters and abstracts. He serves on the Chairman of the Executive Committee of the Council on Cardiovascular Surgery and Anesthesia of the American Heart Association, the Chairman of the Advisory Council on Cardiothoracic Surgery of the American College of Surgeons, Chairman of the Data Safety Monitoring Committee of the National Institutes of Health Cardiac Surgery Network. He is the Past-President of the Massachusetts Society of Thoracic Surgeons, and is a member of numerous other organizations including the American Association for Thoracic Surgery, Society of University Surgeons, and the American Surgical Association. Dr. Sellke is a fellow of the American College of Cardiology, the American College of Chest Physicians, and the American College of Surgeons.

Funded Research

Research Funding Information:
Past:
1988-89 NHLBI Institutional Research Grant Cardiovascular Center, University of
Iowa College of Medicine, Iowa City.

1990-92 Beth Israel Hospital Start-up Grant "Cardioplegia and Coronary
Microvascular Reactivity." [Principal Investigator].

1992-99 NIH T32 HL 07374 "Cardiovascular research training program"
[Co-investigator, James Morgan, PI]

1992-94 Physician-Scientist Award, American College of Chest Physicians

1992-95 American Heart Association, Massachusetts Affiliate Grant-In-Aid.
"Coronary Venous Microvascular Reactivity" 13-501-912.
[Principal Investigator].

1992-97 NIH First Award, "Cardioplegia and Coronary Microvascular Reactivity"
R29 HL-46716. [Principal Investigator].

1996-97 Genentech, Inc. "VEGF in chronic Myocardial Ischemia."
[Co-investigator, Michael Simons, PI].

1996-97 Chiron Corporation, "Intrapericardial administration of basic FGF in
chronic myocardial ischemia. [Co-investigator, Michael Simons, PI].

1996-99 NIH RO1 HL31704. "Regulation of contraction and growth of blood vessels". [Co-investigator, Kathleen Morgan, PI].

1998-01 NIH R01HL 58072. "Magnetic resonance imaging of coronary collaterals". [Co-investigator, Justin Pearlman, PI].

1996-01 NIH 2T32 GM07806. "Academic Training in Trauma and Burns."
[Co-investigator, Michael Simons, PI].

1999-02 NIH RO1 HL62289. "Syndecan function in endothelial cells".
[Co-investigator, Michael Simons, PI].

1996-01 NIH R01 HL53793. "Angiogenesis in Myocardial Ischemia".
[Co-investigator, Michael Simons, PI].


2000-02 NIH. SBRI R43 HL65863-01 "Effect of a PARS inhibitor in myocardial
ischemia reperfusion injury in a porcine model in vivo" [Subcontract PI]

2001-03 Aventis Expedition Study, A double blinded, placebo controlled multinational trial to investigate the effect of IV treatment with the Na+/H+ exhange inhibitor CARIPORIDE (HOE642) on all-cause mortality and non-fatal myocardial infarction in patients at risk for myocardial necrosis during and after coronary artery bypass graft (CABG) surgery (HOE642A/3002). Aventis Pharmaceuticals, Inc. [Center Principal Investigator]

2001-02 Autologous Myoblast Transplantation for the treatment of infarcted myocardium-A pilot study. Diacrin, Inc. [Center Principal Investigator]

1997-03 NIH P50 HL 56993 SCOR Molecular Medicine. Section 6.
Stimulation of human coronary angiogenesis with basic FGF.
[5% Co-investigator, Lew Cantley, PI].

2001-03 "HMG CoA Reductase Inhibitors and Cardiopulmonary Bypass"
NIH Individual National Research Service Award F32 HL69651
Agency: NIH/NHLBI
P.I.: Tanveer Khan Sponsor: Frank W. Sellke

2002-03 NIH NOT-HL-02-003 MicroArray supplement for HL46716-11S1.
[Principal Investigator]

2002-04 Anti-inflammatory and thrombotic effects of aprotinin, Bayer Corp. [Principal Investigator]

2003-2004 Double-Blind Multi-Center Study of the Safety and Efficacy of Parecoxib Followed by Valdecoxib Compared to Placebo for Treatment of Post-Surgical Pain in Patients who have Coronary Bypass Graft Via Median Sternotomy, Pharmacia, [Principal Investigator]

2004-05 CLF "Modulation of coronary angiogenesis in a porcine model of hypercholesterolemia" [Principal Investigator]


2003-06 NIH RO1 HL 072952 "KLF15, TGFb1 and smooth muscle biology"
[5% Collaborating investigator, Mukesh Jain, PI]


2005-06 Therumo Cardiovascular. Effects of non-ischemic acidosis on indices of myocardial dysfunction and apoptosis. [Co-PI].

2005-06 Alexion/ Proctor & Gamble "Primo CABG II study". [Site PI]

2005-06 Inotek Corporation "Phase II randomized, double-blind, placebo-controlled, multicenter study to evaluate tolerability, safety, pharmacokinetics and efficacy of intravenous INO-1001 in high risk subjects undergoing cardiopulmonary bypass for coronary revascularization and/or valve surgery. [International Study Principal Investigator]

2003-06 Mentor to Peter Kang, MD on K08 HL067091-03, NHLBI


2005-07 Pluromed "Legoo internal vessel occluder: effects on endothelial function and myocardial perfusion" [PI]

Present:

1997-09 NIH RO1 HL-46716, "Cardioplegia and Coronary Microvascular Reactivity"
[Principal Investigator].

2001-09 NIH T32 "Cardiovascular research training program"
[Co-investigator, Anthony Rosenzweig, PI]

2002-12 NIH RO1 69024-05 Surgical angiogenesis in a porcine model of chronic myocardial ischemia. [Principal investigator]

2004-09 NIH T32 HL-076130 "Cardiovascular Surgery Research" Training Grant
[Principal Investigator]

2003-08 NIH K-12 Initiatives for teachers and students (MKITS) grant [Co-investigator, Joan Y. Reede, PI]

2004-09 NIH T32 "Research Training in Vascular Surgery"
[Co-investigator, Frank Logerfo, PI]

2004-09 Irving Bard Fellowship. [Mentor for 2 fellows per year]

2006-07 Ikaria, Inc. "Effect of the hydrogen sulfide donor IL-1001 on the outcome of myocardial infarction and cardiopulmonary bypass in the pig". [PI]

2007—11 R01 HL082837-01
The Role of RTEF-1 in Angiogenesis and Myocardial Ischemia
[Co-PI, Jian Li, PI]

2008-09 Orthologic Corporation. Effects of TP508 on Ischemia Reperfusion Injury and Apoptosis in a Porcine Model of Hypercholesterolemia. [PI]

2008-10 NIH RO1 DK 074098-01 "Angiogenesis in a model of diabetes and endothelial dysfunction" [principal investitor]

2009-14 NIH K-99. Small heat shock proteins in surgically-induced myocardial stunning. [Clements RT, PI; Sellke F, Mentor]

Teaching Experience

Clnical Cardiothoracic Surgery and Cardiovascular Research. Undergraduate and graduate students as well as medical students are welcome go participate in clinical and laboratory research.