Faculty Profile: Joanne Lomas-Neira, M.S. Ph.D.

Joanne Lomas-Neira
Joanne Lomas-Neira, M.S. Ph.D.
Assistant Professor of Surgery (Research)
Bio Med Surgery
Work: +1 401-444-7796
My project focuses on endothelial cell-specific mediators, Angiopoietins 1 & 2, and their role in the vascular dysfunction observed in the development of acute lung injury (ALI).

Research Description

My project focuses on endothelial cell-specific mediators, Angiopoietins 1 & 2, and their role in the vascular dysfunction we observe in the development of acute lung injury (ALI). Under physiological conditions, expression of these 2 proteins and their interaction with their shared receptor, Tie2, is tightly regulated. However, in trauma patients and in our shock/sepsis mouse model for the development of ALI, Ang-2 in significantly up-regulated, deleteriously impacting vascular integrity (increased micro-vascular permeability and edema). The aims of my project are to determine the kinetics of Ang-2/Ang-1 change in expression and begin to unravel the mechanisms (cellular and/or molecular) that precipitate loss of pulmonary endothelial barrier function in the development of ALI.

Grants and Awards

Rhode Island Foundation Medical Research Grant 2010-2011
Surgical Infection Society Junior Faculty Fellowship 2011-2012

Affiliations

American Association of Immunologists
American Association for the Advancement of Science
American Society of Investigative Pathology
International Cytokine Society
Shock Society
Society for Leukocyte Biology
Surgical Infection Society

Funded Research

Endothelial Injury and Repair: Cardiopulmonary Vascular Biology COBRE GM103652

Selected Publications

  • Monaghan, S.F., Thakkar, R.K., Heffernan, D.S., Tran, M.L., Huang, X., Chung, C.S., Chen, Y., Lomas-Neira, J.L., Cioffi, W.G., Ayala, A. 2011. Mechanisms of indirect acute lung injury: a novel role for the co-inhibitory receptor, programmed death-1 (PD-1). Ann. Surg. (in press). (PMID: 21997806) (2011)
  • Perl, M., Lomas-Neira, J.L., Venet, F., Chung, C.S., Ayala, A. 2011. Pathogenesis of indirect (secondary) acute lung injury (ALI). Expert Rev. Resp. Med. 5:115-126. (REVIEW; PMID: 21348592). (2011)
  • Perl, M., Chung, C.S., Perl, U., Thakkar, R., Lomas-Neira, J.L., Ayala, A. 2010. Therapeutic accessibility of caspase mediated cell death as a key patho-mechanism in indirect acute lung injury. Crit. Care. Med. 39:1179-86. (PMID: 0154604). (2010)
  • Venet, F., Chung, C.S., Huang, X., Lomas-Neira, J.L., Chen, Y., Ayala, A. 2009. Indirect lung injury: a role for regulatory T lymphocytes in the development of pulmonary inflammation. J. Immunol. 183:3472-80 (PMID: 19641139). (2009)
  • Lomas-Neira, J.L., Chung, C.S., Ayala, A. 2008. RNA interference as a potential therapeutic treatment for inflammation associated lung injury. Inter. J. Clin. Exp. Med. 1:154-160 (REVIEW; PMID: 19079669). (2008)
  • Perl, M., Lomas-Neira, J.L., Chung, C.S., Ayala, A. 2008. Epithelial apoptosis and neutrophil recruitment in acute lung injury - A unifying hypothesis? What we have learned from small interfering RNAs. Mol. Med. 14:465-475 (REVIEW; PMID: 18368145). (2008)
  • Huang, X., Venet, F., Lomas-Neira, J.L., Chung, C.S., Ayala, A. 2007. Changes in dendritic cell function in the immune response to sepsis. Expert Opin. Biol. Ther. 7:929-938 (REVIEW; PMID: 17665984). (2007)
  • Perl, M., Chung, C.S., Perl, U., Lomas-Neira, J.L., De Paepe, M., Cioffi, W.G., Ayala, A. 2007. Fas induced pulmonary apoptosis and inflammation during indirect acute lung injury. Amer. J. Resp. & Crit. Care. Med. 176:591-601 (PMID: 17600273). (2007)
  • Chung, C.S., Watkins, L., Song, G.Y., Lomas-Neira, J.L., Cahoone, E.V., Cioffi, W.G., Ayala, A. 2006. Deficiency in gamma-delta T-lymphocytes compromises the ability of mice to survive polymicrobial sepsis. Amer. J. Physiol. 291:R1338-1343 (PMID:16878028). (2006)
  • Lomas-Neira, J.L., Chung, C.S., Perl, M., Gregory, S., Biffl, W., Ayala, A. 2006. Role of alveolar macrophage & migrating neutrophils in hemorrhage induced priming for ALI subsequent to septic challenge. Amer. J. Physiol. 290:51-58 (PMID: 16157517). (2006)
  • Wesche, D.E., Lomas-Neira, J.L., Perl, M., Chung, C.S., Ayala, A. 2005. Leukocyte apoptosis and its significance in sepsis and shock. J. Leukocyte Biol. 78:325-337 (REVIEW; PMID: 15817707). (2005)
  • Lomas-Neira, J.L., Perl, M., Chung, C.S., Ayala, A. 2005. Shock and hemorrhage: An overview of animal models. Shock 24 (Suplt. 1): 33-39 (REVIEW; PMID: 16374370). (2005)
  • Perl, M., Chung, C.S., Lomas-Neira, J.L., Rachel, T.M., Biffl, W.L., Cioffi, W.G., Ayala, A. 2005. Silencing of Fas- but not caspase-8 in lung epithelial cells ameliorates experimental acute lung injury. Amer. J. Pathol. 167:1545-559 (PMID: 16314469). (2005)
  • Wesche-Soldato, D.E., Chung, C.S., Lomas-Neira, J.L., Doughty, L.A., Gregory S. H., Ayala, A. 2005. In vivo delivery of caspase 8 or FAS siRNA impoves the survival of septic mice. Blood. 106:2295-2301 (PMID: 15941915). (2005)
  • Lomas-Neira, J.L., Chung, C.S., Wesche, D.E., Perl, M., Ayala, A. 2005. In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 vs. KC results in divergent effects on hemorrhage induced neutrophil mediated septic acute lung injury. J. Leukocyte Biol. 77:846-853 (PMID: 15695553). (2005)
  • Lomas-Neira, J.L., Chung, C.S., Grutkoski, P.S., Miller, E.J., Ayala, A. 2004. CXCR2 inhibition suppresses hemorrhage induced priming for acute lung injury in mice. J. Leukoc. Biol. 76:58-64 (PMID: 15123771). (2004)
  • Rhee, R.J., Carlton, S., Lomas, J.L., Lane, C., Brossay, L., Ayala, A. 2003. Inhibition of CD1d activation suppresses septic mortality: a role for NK-T cells in septic immune dysfunction. J. Surg. Res. 115:74-81 (PMID: 14572776). (2003)
  • Lomas, J.L., Chung, C.S., Grutkoski, P.S., LeBlanc, B.W., Lavigne, L., Reichner, J., Gregory, S.H., Doughty, L.A., Cioffi, W.G., Ayala, A. 2003. Differential effects of MIP-2 and KC on hemorrhage induced neutrophil priming for lung inflammation: assessment by adoptive cell transfer in mice. Shock 19:358-365 (PMID: 12688548). (2003)
  • Chung, C.S., Song, G.Y., Lomas, J.L., Simms, H.H., Chaudry, I.H., Ayala, A. 2003. Inhibition of Fas/Fas ligand (FasL) signaling during sepsis has tissue specific effects on macrophage apoptotic and functional capacity. J. Leukocyte Biol. 74:344-351 (PMID: 12949237) (2003)
  • Ayala, A., Chung, C.S., Lomas, J.L., Song, G.Y., Doughty, L.A., Gregory, S.H., Cioffi,W.G., LeBlanc, B.W., Reichner, J., Simms, H.H., Grutkoski, P.S. 2002. Shock induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Amer. J. Pathology 161:2283-2294 (PMID: 12466142). (2002)