Faculty Profile: Jorge Castillo, MD

Jorge Castillo
Jorge Castillo, MD
Assistant Professor of Medicine
Medicine
Work: +1 401-793-7151
Dr. Castillo's main research interests focus on the epidemiology, prognostic factors, diagnosis and therapy of lymphomas and HIV/AIDS-related malignancies. His most recent research efforts are directed to improve the understanding of rare types of lymphoma such as plasmablastic and T-cell lymphomas and their potential association with oncoviruses, such as EBV. He is also interested on studying the epidemiology and risk factors for lymphoma development using meta-analytical methodologies.

Biography

Dr. Castillo was born in Trujillo, Peru and obtained his Medical Degree in Mexico City, Mexico in 1996. He completed his Internal Medicine Residency in Framingham, MA, where he also was the Chief Medical Resident, and was a Fellow in Hematology and Oncology at Brown University. Currently he is Assistant Professor of Medicine at the Warren Alpert Medical School of Brown University with research interests focus on the epidemiology, prognostic factors, diagnosis and therapy of lymphomas and HIV/AIDS-related malignancies and the study of lymphoma epidemiology using meta-analytical methodologies.

Research Description

Principal investigator; Retrospective multi-institutional study on the prognostic factors of HIV-associated Kaposi sarcoma, 2011

Principal investigator; Retrospective multi-institutional study on the prognostic factors of HIV-associated Hodgkin lymphoma, 2011

Principal investigator; Meta-analysis of observational studies on the relationship between body mass index and the risk of developing hematological malignancies, 2011

Principal investigator; Retrospective multi-institutional study on the clinicopathological characteristics and prognostic factors of HIV-associated plasmablastic lymphoma, 2011

Principal investigator; Meta-analysis of observational studies on the relationship between cigarette smoking and the risk of developing leukemia, lymphoma and myeloma, 2011

Principal investigator; Meta-analysis of observational studies on the relationship between type 2 diabetes mellitus and the risk of developing hematological malignancies, 2010

Principal investigator; Phase II trial of ofatumumab and bortezomib in patients with low-grade non-Hodgkin lymphoma that relapsed beyond 6 months after rituximab-containing therapy, 2010

Principal investigator; Retrospective multi-institutional study on the clinicopathological characteristics and prognostic factors of HIV-associated peripheral T-cell lymphomas, 2010

Mentor; Retrospective study on the different prognostic factors in patients with aggressive variants of adult T-cell leukemia/lymphoma, 2010

Principal investigator; Retrospective study on prognostic factors for survival in patients with diffuse large B-cell lymphoma treated in Rhode Island, 2010

Mentor; Retrospective study on the incidence of Clostridium difficile infection in febrile neutropenic oncology patients, 2010

Mentor; Retrospective study on the prognostic value of lymphopenia in patients with peripheral T-cell lymphoma, unspecified, 2010

Mentor; Retrospective study on the prognostic role of EBV-encoded RNA expression by tumor cells in de novo diffuse large B-cell lymphoma in a Peruvian population, 2009

Principal investigator; Meta-analysis of observational studies on the relationship between allogeneic red blood cell transfusions and the risk of developing non-Hodgkin lymphoma, 2009

Principal investigator; Retrospective study on the clinical characteristics and outcomes of patients with AIDS-related lymphomas in Rhode Island, 2008

Co-principal investigator; Meta-analysis of observational studies on the relationship between type II diabetes mellitus and the risk of developing non-Hodgkin lymphoma, 2008

Principal investigator; Literature search on the clinicopathological characteristics of HIV-associated plasmablastic lymphomas, 2008

Principal investigator; Literature search on the clinicopathological characteristics of HIV-associated peripheral T-cell lymphomas, 2007

Grants and Awards

Healthcare Professional Award; Leukemia & Lymphoma Society – Rhode Island Chapter, December 2011
Certificate of Recognition for Exemplary Teaching; The Warren Alpert Medical School of Brown University, Providence, RI, June 2011
Certificate of Recognition for Exemplary Teaching; The Warren Alpert Medical School of Brown University, Providence, RI, June 2010
Chief Medical Resident, MetroWest Medical Center, Framingham, MA, 2004-2005

Affiliations

Member; Steering Committee, New England Lymphoma Rounds. Sponsored by the Lymphoma Research Foundation (LRF), 2011-
Member; AIDS and Cancer Specimen Resource (ACSR) Research Evaluation and Decision Panel, 2011-
Junior Member; European Hematology Association, 2010-
Member, Board of Trustees; Leukemia & Lymphoma Society, Rhode Island Chapter, 2009-
AIDS Malignancies Consortium (AMC), 2009-
Center for AIDS Research (CFAR), 2009-
Rhode Island Medical Society, 2008-
Brown University Oncology Group (BrUOG), 2007-
American Society of Hematology (ASH), 2005-
American Society of Clinical Oncology (ASCO), 2005-
American College of Physicians/American Society of Internal Medicine (ACP/ASIM), 2002-2005
Medical College of Peru, 1997-2001
Mexican Association of General Physicians, 1996

Funded Research

GlaxoSmithKline and Millenium Pharmaceuticals. Phase II trial of ofatumumab and bortezomib in patients with relapsed indolent non-Hodgkin lymphoma. $400K. September 2009.

Teaching Experience

Small Group Leader; BioMed Pathophysiology, BIOL3672IMF4: Hematology Section, The Warren Alpert Medical School of Brown University, January 2009
Small Group Leader; BioMed Pathophysiology, BIOL3672IMSIV: Hematology Section, The Warren Alpert Medical School of Brown University, January 2010.
Small Group Leader; BioMed Pathophysiology, BIOL3672IMSIV: Hematology Section, The Warren Alpert Medical School of Brown University, January 2011.

Selected Publications

  • Beltran BE, Quinones P, Morales D, Revilla J, Alva J, Castillo JJ. Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type-1 Carriers. Leukemia Research and Treatment, January 2012; 2012: 262363. (2012)
  • Wang CC, Castillo JJ. Management of HIV-Associated Lymphomas. Medicine & Health Rhode Island, January 2011; 94(1): 4-6. (2011)
  • Castillo JJ, Beltran BE, Miranda RN, Paydas S, Winer ES, Butera JN. EBV-positive diffuse large B-cell lymphoma of the elderly: what we know so far. The Oncologist, January 2011; 16(1): 87-96. (2011)
  • Beltran BE, Castillo JJ, Salas R, Quinones P, Morales D, Cotrina E, Miranda RN, Sotomayor EM. Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone: report of two cases from South America. Leukemia and Lymphoma, January 2011; (52)1: 153-156. (2011)
  • Reagan JL, Castillo JJ. Ofatumumab for untreated and relapsed/refractory chronic lymphocytic leukemia. Expert Review on Anticancer Therapy, February 2011; 11(2): 151-160. (2011)
  • Beltran B, Morales D, Quinones P, Cotrina E, Castillo JJ. Different prognostic factors for survival in acute and lymphomatous adult T-cell leukemia/lymphoma. Leukemia Research, March 2011; (35)3: 334-339. (2011)
  • Castillo JJ, Beltran BE, Bibas M, Bower M, Collins JA, Cwynarski K, Diez-Martin JL, Hernandez-Ilizaliturri F, Horwitz SM, Montoto S, Pantanowitz L, Ribera JM, Vose JM. Prognostic factors in patients with HIV-associated peripheral T-cell lymphoma: a multicenter study. American Journal of Hematology, March 2011; 86(3): 256-261. (2011)
  • Mazzaglia PJ, Strenger R, Castillo JJ. Extramedullary relapse of acute myeloid leukemia in a surgical wound. Leukemia and Lymphoma, March 2011; 52(3): 541-543. (2011)
  • Castillo JJ, Winer ES, Stachurski D, Perez K, Jabbour M, Milani C, Colvin G, Butera JN. HIV-negative plasmablastic lymphoma: not in the mouth. Clinical Lymphoma, Myeloma & Leukemia, April 2011; 11(2): 185-189. (2011)
  • Beltran BE, Castillo JJ, Morales D, Hurtado de Mendoza F, Quinones P, Miranda RN, Gallo A, Lopez-Ilasaca M, Butera JN, Sotomayor EM. EBV-positive diffuse large B-cell lymphoma of the elderly: A case series from Peru. American Journal of Hematology, August 2011; 86(8): 663-667. (2011)
  • Castillo JJ, Sinclair N, Stachurski D, Jacobsen ED. Positive HIV ELISA test, autoimmune hemolytic anemia and generalized lymphadenopathy: A unifying diagnosis. American Journal of Hematology, August 2011; 86(8): 690-693. (2011)
  • Jabbour M, Tuncer H, Castillo JJ, Butera JN, Roy T, Pojani J, Al-Malki M, Al-Homsi S. Hematopoietic Stem Cell Transplantation for Adult T-Cell Leukemia/ Lymphoma: A Review. Bone Marrow Transplantation, August 2011; 46(8): 1039-1044. (2011)
  • Castillo JJ, Dalia S, Shum H. Meta-analysis on the association between cigarette smoking and incidence of Hodgkin's lymphoma. Journal of Clinical Oncology, October 2011; 29(29): 3900-3906. (2011)
  • Castillo JJ. Plasmablastic lymphoma: are more intensive therapies needed? Leukemia Research, December 2011; 35(12): 1547-1548. (2011)
  • Beltran BE, Morales D, Quinones P, Medeiros LJ, Miranda RN, Castillo JJ. EBV-positive diffuse large B-cell lymphoma in young immunocompetent individuals. Clinical Lymphoma, Myeloma & Leukemia, December 2011; 11(6): 512-516. (2011)
  • Beltran BE, Morales D, Quinones P, Miranda RN, Goswami M, Castillo JJ. Peripheral T-Cell Lymphoma with a Regulatory T-Cell Phenotype: Report of a Nodal and an Extranodal Case from Peru. Applied Immunohistochemistry & Molecular Morphology. August 10 2011 [Epub ahead of print] (2011)
  • Castillo JJ, Furman M, Winer ES. CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies. Expert Opinion on Investigational Drugs. November 24 2011 [Epub ahead of print] (2011)
  • Castillo JJ, Reagan JL. Plasmablastic lymphoma: a systematic review. The Scientific World Journal, March 2011; (11): 687-696. (2011)
  • Berz D, Castillo JJ, Quilliam DN, Colvin G. Pesticides and non-Hodgkin lymphoma: An overview for the clinician. Medicine & Health Rhode Island, January 2011; 94(1): 10-12. (2011)
  • Castillo J, Perez K. The role of ofatumumab in the treatment of chronic lymphocytic leukemia resistant to previous therapies. Journal of Blood Medicine, February 2010; 1(1): 1-8. (2010)
  • Dalia S, Milani C, Castillo J, Mega A, Schiffman F. Fooled by the fragments: Masquerading microangiopathy. Medicine & Health Rhode Island, January 2010; 93(1): 25-26. (2010)
  • Morales D, Beltran B, Hurtado de Mendoza F, Riva L, Yabar A, Quinones P, Butera JN, Castillo J. EBV as a prognostic factor in de novo nodal diffuse large B-cell lymphoma. Leukemia and Lymphoma, January 2010; 51(1): 66-72. (2010)
  • Perez K, Castillo J, Dezube BJ, Pantanowitz L. HIV-associated anaplastic large cell lymphoma. Leukemia and Lymphoma, March 2010; 51(3): 430-438. (2010)
  • Castillo JJ, Winer ES, Stachurski D, Perez K, Jabbour M, Milani C, Colvin G, Butera JN. Prognostic factors in chemotherapy treated patients with HIV-associated plasmablastic lymphoma. The Oncologist, March 2010; 15(3): 293-299. (2010)
  • Castillo JJ, Morales D, Quinones P, Cotrina E, Beltran B. Lymphopenia as a prognostic factor in patients with peripheral T-cell lymphoma, unspecified. Leukemia and Lymphoma, October 2010; 51(10): 1822-1828. (2010)
  • Castillo JJ, Dalia S, Pascual SK. Association between red blood cell transfusions and the development of non-Hodgkin lymphoma: a meta-analysis of observational studies. Blood, October 2010; 116(16): 2897-2907. (2010)
  • Castillo JJ, Rizack T, Treaba D. Immunophenotypical switch versus tumor heterogeneity in a patient with HIV-associated diffuse large B-cell lymphoma. Pathology Research International, October 2010; 2011: 563216. (2010)
  • Castillo JJ, Winer ES, Stachurski D, Perez K, Jabbour M, Milani C, Colvin G, Butera JN. Clinical and pathological differences between HIV-positive and HIV-negative patients with plasmablastic lymphoma. Leukemia and Lymphoma, November 2010; 51(11): 2047-2053. (2010)
  • Alduaij A, Butera JN, Treaba D, Castillo JJ. Complete Remission in Two Cases of Adult T-Cell Leukemia/Lymphoma Treated With Hyper-CVAD: A Case Report and Review of the Literature. Clinical Lymphoma, Myeloma & Leukemia, December 2010; 10(6): 480-483. (2010)
  • Layton J, Castillo JJ. Non-AIDS-defining cancers. Medicine & Health Rhode Island, October 2010; 93(10): 296-299. (2010)
  • Beltran B, Winer E, Castillo J. ALK-positive diffuse large B-cell lymphoma: An aggressive clinicopathological entity. European Journal of Clinical & Medical Oncology, February 2010; 2(1): 155-161. (2010)
  • Pantanowitz L, Castillo J, Freeman J, Dezube B. Images in HIV/AIDS. Fatal HIV-associated anaplastic large-cell lymphoma. The AIDS Reader, January 2009; 19(1): 19-21. (2009)
  • Beltran B, Castillo J, Salas R, Quinones P, Morales D, Hurtado F, Riva L, Winer E. ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature. Journal of Hematology & Oncology, February 2009; 2(1): 11. (2009)
  • Milani C, Castillo J. Veltuzumab, an anti-CD20 monoclonal antibody for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. Current Opinion in Molecular Therapeutics, April 2009; 11(2): 200-207. (2009)
  • Castillo J, Perez K, Milani C, Pantanowitz L, Dezube B. HIV-associated peripheral T-cell lymphoma: A comprehensive review. Journal of HIV Therapy, June 2009; 14(2): 34-40. (2009)
  • Beltran B, Salas R, Quinones P, Morales D, Hurtado F, Cotrina E, Riva L, Castillo J. EBV-positive diffuse large B-cell lymphoma in a HTLV-I carrier. Infectious Agents and Cancer, July 2009; 4(1): 10. (2009)
  • Hebert H, Butera JN, Castillo J, Mega AE. Are we training our fellows adequately in delivering bad news to patients? A survey of Hematology/Oncology Program Directors. Journal of Palliative Medicine, December 2009; 12(12): 1119-1124. (2009)
  • Rizack T, Mega A, Legare R, Castillo J. Management of hematological malignancies during pregnancy. American Journal of Hematology, December 2009; 84(12): 830-841. (2009)
  • Castillo J, Milani C, Mendez D. Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders. Expert Opinion on Investigational Drugs, April 2009; 18(4): 491-500. (2009)
  • Castillo J, Dezube B, Pantanowitz L. Plasmablastic lymphoma in HIV: Lessons learned from 112 published cases. American Journal of Hematology, October 2008; 83(10): 804-809. (2008)
  • Castillo J, Hansen C, Mega A, Tashima K. AIDS-related lymphomas: The Rhode Island experience. Medicine & Health Rhode Island, November 2008; 91(11): 332-334. (2008)
  • Mitri J, Castillo J, Pittas A. Diabetes and risk of non-Hodgkin lymphoma: A meta-analysis of observational studies. Diabetes Care, December 2008; 31(12): 2391-2397. (2008)
  • Castillo J, Winer E, Quesenberry P. Newer monoclonal antibodies for hematological malignancies. Experimental Hematology, July 2008; 36(7): 755-768. (2008)
  • Castillo J, Dezube B, Pantanowitz L. Noteworthy features of HIV-associated T-cell lymphoma. HIV & AIDS Review, December 2007; 6(4): 26-30. (2007)