Faculty Profile: Dmitry Terentyev

Dmitry Terentyev
Assistant Professor of Medicine (Research)
Bio Med Medicine
Work: +1 401-444-0392

Selected Publications

  • 1: Belevych AE, Terentyev D, Terentyeva R, Ho HT, Gyorke I, Bonilla IM, Carnes CA, Billman GE, Györke S. Shortened Ca2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death. Circ Res. 2012 Jan 5. [Epub ahead of print] PubMed PMID: 22223353. (2012)
  • 8: Belevych AE, Sansom SE, Terentyeva R, Ho HT, Nishijima Y, Martin MM, Jindal HK, Rochira JA, Kunitomo Y, Abdellatif M, Carnes CA, Elton TS, Györke S, Terentyev D. MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex. PLoS One. 2011;6(12):e28324. Epub 2011 Dec 6. PubMed PMID: 22163007; PubMed Central PMCID: PMC3232211. (2011)
  • 7: Elton TS, Khan M, Terentyev D. MicroRNAs in cardiovascular disease. F1000 Med Rep. 2011;3:10. Epub 2011 May 3. PubMed PMID: 21654926; PubMed Central PMCID: PMC3096884. (2011)
  • 6: Elton TS, Martin MM, Sansom SE, Belevych AE, Györke S, Terentyev D. miRNAs got rhythm. Life Sci. 2011 Feb 28;88(9-10):373-83. Epub 2010 Dec 3. Review. PubMed PMID: 21130781. (2011)
  • 5: Belevych AE, Terentyev D, Terentyeva R, Nishijima Y, Sridhar A, Hamlin RL,Carnes CA, Györke S. The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function. Cardiovasc Res. 2011 Jun 1;90(3):493-502. Epub 2011 Jan 27. PubMed PMID: 21273243; PubMed Central PMCID: PMC3096306. (2011)
  • 3: Ho HT, Stevens SC, Terentyeva R, Carnes CA, Terentyev D, Györke S. Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J Physiol. 2011 Oct 1;589(Pt 19):4697-708. Epub 2011 Aug 1. PubMed PMID: 21807619; PubMed Central PMCID: PMC3213417. (2011)
  • 2: Kunitomo Y, Terentyev D. How to stop the fire? Control of Ca²⁺-induced Ca²⁺ release in cardiac muscle. J Physiol. 2011 Dec 15;589(Pt 24):5899-900. PubMed PMID: 22174133. (2011)
  • 4: Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, Li C,Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA. Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology. Cardiovasc Res. 2011 Jul 1;91(1):71-9. Epub 2011 Apr 1. PubMed PMID: 21460065; PubMed Central PMCID: PMC3112023. (2011)
  • 9: Billman GE, Nishijima Y, Belevych AE, Terentyev D, Xu Y, Haizlip KM, Monasky MM, Hiranandani N, Harris WS, Gyorke S, Carnes CA, Janssen PM. Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies. Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1219-28. Epub 2010 Jan 22. PubMed PMID: 20097770; PubMed Central PMCID: PMC2853418. (2010)
  • 13: Györke S, Stevens SC, Terentyev D. Cardiac calsequestrin: quest inside the SR. J Physiol. 2009 Jul 1;587(Pt 13):3091-4. Review. PubMed PMID: 19567748; PubMed Central PMCID: PMC2727018. (2009)
  • 12: Stevens SC, Terentyev D, Kalyanasundaram A, Periasamy M, Györke S. Intra-sarcoplasmic reticulum Ca2+ oscillations are driven by dynamic regulation of ryanodine receptor function by luminal Ca2+ in cardiomyocytes. J Physiol. 2009 Oct 15;587(Pt 20):4863-72. Epub 2009 Aug 24. PubMed PMID: 19703963; PubMed Central PMCID: PMC2770152. (2009)
  • 10: Belevych AE, Terentyev D, Viatchenko-Karpinski S, Terentyeva R, Sridhar A, Nishijima Y, Wilson LD, Cardounel AJ, Laurita KR, Carnes CA, Billman GE, Gyorke S. Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death. Cardiovasc Res. 2009 Dec 1;84(3):387-95. Epub 2009 Jul 17. PubMed PMID: 19617226; PubMed Central PMCID: PMC2777950. (2009)
  • 11: Sridhar A, Nishijima Y, Terentyev D, Khan M, Terentyeva R, Hamlin RL,Nakayama T, Gyorke S, Cardounel AJ, Carnes CA. Chronic heart failure and the substrate for atrial fibrillation. Cardiovasc Res. 2009 Nov 1;84(2):227-36. Epub 2009 Jun 30. PubMed PMID: 19567484; PubMed Central PMCID: PMC2761201. (2009)
  • 14: Terentyev D, Belevych AE, Terentyeva R, Martin MM, Malana GE, Kuhn DE,Abdellatif M, Feldman DS, Elton TS, Györke S. miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2. Circ Res. 2009 Feb 27;104(4):514-21. Epub 2009 Jan 8. PubMed PMID: 19131648. (2009)
  • 18: Györke S, Terentyev D. Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc Res. 2008 Jan 15;77(2):245-55. Epub 2007 Oct 15. Review. PubMed PMID: 18006456. (2008)
  • 17: Terentyev D, Kubalova Z, Valle G, Nori A, Vedamoorthyrao S, Terentyeva R, Viatchenko-Karpinski S, Bers DM, Williams SC, Volpe P, Gyorke S. Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death. Biophys J. 2008 Aug;95(4):2037-48. Epub 2008 May 9. PubMed PMID: 18469084; PubMed Central PMCID: PMC2483765. (2008)
  • 16: Sridhar A, Nishijima Y, Terentyev D, Terentyeva R, Uelmen R, Kukielka M,Bonilla IM, Robertson GA, Györke S, Billman GE, Carnes CA. Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1463-72. Epub 2008 Sep 3. PubMed PMID: 18768760; PubMed Central PMCID: PMC2584860. (2008)
  • 15: Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S. Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure. Circ Res. 2008 Dec 5;103(12):1466-72. Epub 2008 Nov 13. PubMed PMID: 19008475; PubMed Central PMCID: PMC3274754. (2008)
  • 22: Dirksen WP, Lacombe VA, Chi M, Kalyanasundaram A, Viatchenko-Karpinski S, Terentyev D, Zhou Z, Vedamoorthyrao S, Li N, Chiamvimonvat N, Carnes CA, Franzini-Armstrong C, Györke S, Periasamy M. A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice. Cardiovasc Res. 2007 Jul 1;75(1):69-78. Epub 2007 Mar 12. PubMed PMID: 17449018; PubMed Central PMCID: PMC2717009. (2007)
  • 21: Terentyev D, Viatchenko-Karpinski S, Vedamoorthyrao S, Oduru S, Györke I, Williams SC, Györke S. Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes. J Physiol. 2007 Aug 15;583(Pt 1):71-80. Epub 2007 Jun 14. PubMed PMID: 17569730; PubMed Central PMCID: PMC2277233. (2007)
  • 20: Lacombe VA, Viatchenko-Karpinski S, Terentyev D, Sridhar A, Emani S, Bonagura JD, Feldman DS, Györke S, Carnes CA. Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1787-97. Epub 2007 Aug 29. PubMed PMID: 17761517; PubMed Central PMCID: PMC2413069. (2007)
  • 19: Belevych A, Kubalova Z, Terentyev D, Hamlin RL, Carnes CA, Györke S. Enhanced ryanodine receptor-mediated calcium leak determines reduced sarcoplasmic reticulum calcium content in chronic canine heart failure. Biophys J. 2007 Dec 1;93(11):4083-92. Epub 2007 Sep 7. PubMed PMID: 17827226; PubMed Central PMCID: PMC2084235. (2007)
  • 26: Terentyev D, Nori A, Santoro M, Viatchenko-Karpinski S, Kubalova Z, Gyorke I, Terentyeva R, Vedamoorthyrao S, Blom NA, Valle G, Napolitano C, Williams SC, Volpe P, Priori SG, Gyorke S. Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death. Circ Res. 2006 May 12;98(9):1151-8. Epub 2006 Apr 6. PubMed Res. 2009 Feb 27;104(4):514-21. Epub 2009 Jan 8. PubMed PMID: 19131648. (2006)
  • 25: di Barletta MR, Viatchenko-Karpinski S, Nori A, Memmi M, Terentyev D, Turcato F, Valle G, Rizzi N, Napolitano C, Gyorke S, Volpe P, Priori SG. Clinical phenotype and functional characterization of CASQ2 mutations associated with catecholaminergic polymorphic ventricular tachycardia. Circulation. 2006 Sep 5;114(10):1012-9. Epub 2006 Aug 14. PubMed PMID: 16908766. (2006)
  • 24: Shiner EK, Terentyev D, Bryan A, Sennoune S, Martinez-Zaguilan R, Li G, Gyorke S, Williams SC, Rumbaugh KP. Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling. Cell Microbiol. 2006 Oct;8(10):1601-10. PubMed PMID: 16984415. (2006)
  • 29: Terentyev D, Cala SE, Houle TD, Viatchenko-Karpinski S, Gyorke I, Terentyeva R, Williams SC, Gyorke S. Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes. Circ Res. 2005 Apr 1;96(6):651-8. Epub 2005 Feb 24. PubMed PMID: 15731460. (2005)
  • 27: Kubalova Z, Terentyev D, Viatchenko-Karpinski S, Nishijima Y, Györke I, Terentyeva R, da Cuñha DN, Sridhar A, Feldman DS, Hamlin RL, Carnes CA, Györke S. Abnormal intrastore calcium signaling in chronic heart failure. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14104-9. Epub 2005 Sep 19. PubMed PMID: 16172392; PubMed Central PMCID: PMC1236548. (2005)
  • 28: Viatchenko-Karpinski S, Terentyev D, Jenkins LA, Lutherer LO, Györke S. Synergistic interactions between Ca2+ entries through L-type Ca2+ channels and Na+-Ca2+ exchanger in normal and failing rat heart. J Physiol. 2005 Sep 1;567(Pt 2):493-504. Epub 2005 Jun 23. PubMed PMID: 15975978; PubMed Central PMCID: PMC1474206. (2005)
  • 31: Viatchenko-Karpinski S, Terentyev D, Györke I, Terentyeva R, Volpe P, Priori SG, Napolitano C, Nori A, Williams SC, Györke S. Abnormal calcium signaling and sudden cardiac death associated with mutation of calsequestrin. Circ Res. 2004 Mar 5;94(4):471-7. Epub 2004 Jan 8. PubMed PMID: 14715535. (2004)
  • 30: Kubalova Z, Györke I, Terentyeva R, Viatchenko-Karpinski S, Terentyev D, Williams SC, Györke S. Modulation of cytosolic and intra-sarcoplasmic reticulum calcium waves by calsequestrin in rat cardiac myocytes. J Physiol. 2004 Dec 1;561(Pt 2):515-24. Epub 2004 Oct 14. PubMed PMID: 15486014; PubMed Central PMCID: PMC1665374. (2004)
  • 32: Györke S, Györke I, Terentyev D, Viatchenko-Karpinski S, Williams SC. Modulation of sarcoplasmic reticulum calcium release by calsequestrin in cardiac myocytes. Biol Res. 2004;37(4):603-7. PubMed PMID: 15709687. (2004)
  • 34: Terentyev D, Viatchenko-Karpinski S, Györke I, Volpe P, Williams SC, Györke S. Calsequestrin determines the functional size and stability of cardiac intracellular calcium stores: Mechanism for hereditary arrhythmia. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11759-64. Epub 2003 Sep 16. PubMed PMID: 13130076;PubMed Central PMCID: PMC208831. (2003)
  • 33: Terentyev D, Viatchenko-Karpinski S, Gyorke I, Terentyeva R, Gyorke S. Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes. J Physiol. 2003 Oct 1;552(Pt 1):109-18. Epub 2003 Aug 1. PubMed PMID: 12897175; PubMed Central PMCID: PMC2343319. (2003)
  • 35: Terentyev D, Viatchenko-Karpinski S, Valdivia HH, Escobar AL, Györke S. Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes. Circ Res. 2002 Sep 6;91(5):414-20. PubMed PMID: 12215490. (2002)
  • 36: Györke S, Györke I, Lukyanenko V, Terentyev D, Viatchenko-Karpinski S, Wiesner TF. Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle. Front Biosci. 2002 Jun 1;7:d1454-63. Review. PubMed PMID: 12045014. (2002)
  • 37: Nasledov GA, Katina IE, Terentyev DA, Tomilin NV, Lukyanenko VI. Development of muscle-specific features in cultured frog embryonic skeletal myocytes. J Muscle Res Cell Motil. 1999 Aug;20(5-6):517-27. PubMed PMID: 10555070. (1999)
  • 38: Lukyanenko V, Katina IE, Nasledov GA, Terentyev DA. Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria. Gen Physiol Biophys. 1995 Dec;14(6):525-34. PubMed PMID: 8773494. (1995)
  • 39: Lukyanenko V, Katina IE, Nasledov GA, Terentyev DA. Beta-adrenergic regulation of voltage-dependent calcium currents in cultured skeletal myocytes of the frog Rana temporaria. Gen Physiol Biophys. 1995 Dec;14(6):515-23. PubMed PMID: 8773493. (1995)
  • 23: Györke S, Hagen BM, Terentyev D, Lederer WJ. Chain-reaction Ca(2+) signaling in the heart. J Clin Invest. 2007 Jul;117(7):1758-62. PubMed PMID: 17607353; PubMed Central PMCID: PMC1904329. (1904)