Dr. Simin Liu led an effort to measure sex hormone binding globulin, of which low levels can indicate elevated risk of type 2 diabetes, in 13,457 women. Researchers provided reference range for blood levels of SHBG across 4 main ethnic populations in the United States and found age, use of estrogen replacement therapy, physical activity, and caffeinated coffee drinking were significantly associated with higher SHBG levels, whereas a high BMI was associated with low SHBG levels. Researchers also found that these associations did not vary by ethnic group. Professor Liu commented that the study supports the idea of adding SHBG, which is readily detectable in clinical blood work, to the standard of preventive care for patients at potential risk for type 2 diabetes.
Lifestyle factors, age related to early biomarker of diabetes
October 3, 2013