Alex Loosley

Alex J. Loosley 

 

Contact:

Phone (Lab): 401-863-1405
Email: aloosley@brown.edu 

Alex Loosley: Biking next to the Charles River, BostonAlex Loosley: Biking next to the Charles River, Boston

Bio
Alex Loosley hails from Simon Fraser University (SFU) where he earned a B.Sc. in Physics and a minor in Business. During his senior year, he studied the role of positive feedback in biological oscillators with Prof. Eldon Emberly. Alex recently completed his Ph.D at Brown University under supervision and tutelage from Prof. Jay Tang's and Prof. Jonathan Reichner studying cellular traction forces and effects of substrate rigidity on cell motility and function.

Education
Simon Fraser University (2003-2008) - B.Sc. - Physics
Brown University (2009-2014) - Sc.M / Ph.D. - Physics

Research Interests:
Mechanobiology and Mechanical Models of Cell Locomotion
Nonlinear Dynamics in Biological Systems 

Posters

  1. BPS Annual Meeting @ San Francisco, 2014.
    Quantification of Directional Motility by a Characteristic Directionality Time.
  2. BPS Mechanobiology @ MDIBL, 2013.
    Human Neutrophil Chemotaxis is a Function of Matrix Composition and Stiffness.

Publications

  1. Xian M. O'Brien, Alex J. Loosley, Katie E. Oakley, Jay X. Tang, and Jonathan S. Reichner. 
    Technical Advance: Introducing a novel metric, directionality time, to quantify human neutrophil chemotaxis as a function of matrix composition and stiffness.
    J Leukocyte Biol, 95: 993-1004 (2014) 
  2. Alex J. Loosley and Jay X. Tang. 
    Stick-slip motion and elastic coupling in crawling cells.
    Phys Rev E, 86: 031908 (2012)

Code

  1. Directed Migration Class - used for random walk simulations and kinematic analysis of cell motion

Condensed CV

Available Here

Videos and Raw Data

  1. Youtube video introducing random variables and distributions
  2. Raw cell trajectories for the directionality time manuscript