Selected Research Projects

I work on understanding evolution by natural selection at the finest scales possible using complementary theoretical and experimental methods. For example, we have considerable experience dissecting the patterns, determinants and consequences of epistasis in the TEM-1 ß-lactamase gene, which can confern bacterial resistance to ß-lactam antibiotics such as penicillin and cephalosporins.

Other current work explores evolution in temporally varying environments, the evolution of mutation rate and the evolution of mutational robustness. We also have a nascent interest in the evolutionary dynamics of cancer.