Research

Understanding PP1, the ubiquitous enzyme

The company it keeps

The enzyme PP1, the tan mass above, is everywhere in the body and has a role in nearly every biological process. That role is shaped more than 200 regulatory proteins that bind to PP1, including one called PNUTS, blue and pink above. Credit: Page lab/Brown University

The enzyme PP1 has a key role in many of the body’s healthy functions and diseases. It’s so generally important that drug developers dare not target it. In a new study in the Proceedings of the National Academy of Sciences, Brown University scientists report a big leap in understanding how PP1 interacts with other proteins to behave specifically in distinct situations. That could lead to medicines that target it for precise benefits.