Joel W. Adelson

M.D., University of California, San Francisco; Ph.D., University of Southern California, 1967
Professor of Pediatrics and Physiology
Department of Molecular Pharmacology, Physiology
& Biotechnology
Pediatrics, Rhode Island Hospital
Tel. (401) 863-8306

Research Summary

Heterogeneity of the exocrine pancreas, non-pamuel secretion of digestive enzymes. Secretagogue-selective packaging and secretion of digestive enzymes from heterogeneous sources within the exocrine pancreas--physiological. studies and morphological studies employing lectin staining.

Non-parallel enzyme secretion by the pancreas of the conscious rat.
The molecular origins of complexity in higher physiological systems.
The use of lactase-treated milk to ameliorate acute diaithea in infants in a Third World setting.
Ischemic-reperfusion injury of the bowel: relationship to necrotizing enterocolitis.

Representative Publications

Adelson JW, DeChadarevian JP, Azouz ME, and Guttman F. Massive obstructive polyposis: A complication of healed ulcerative colitis. J Ped Gastroenterol and Nutrit, 1988, 7:135-140.

Adelson JW, Coutu JA, Gardiner MF, Shalon LB, and Morisset J. Rapid cyclic changes in digestive enzyme proportions and intrapancreatic sources during basal or stimulated enzyme secretion in the individual rabbit. Gastroenterol., 1993, 104:A293.

Adelson JW, Coutu JA. The role of cholecystokinin in pancreatic digestive enzyme secretion. International CCK meeting, Chatham, Massachusetts (U.S.A.), May, 1993.

Adelson JW, Coutu JA, Gardiner UF. Cyclic enzyme secretion from heterogeneous pulse-labeled intrapancreatic sources during secretagogue stimulation: a new paradigm for the physiologic mechanism of pancreatic secretion. Gastroenterol., 1994. (accepted).