Email: [email protected]

  Research Area:

Pulmonary circulation

  Research Summary:

 (1) Role of atrial natriuretic peptide (ANP) in regulation of pulmonary vascular-tone during chronic hypoxia (2) Effect of chronic hypoxia on cardiac synthesis and secretion of ANP

Pulications: Klinger, J.R. and Hill, N.S. Right ventricular dysfunction in chronic obstructive pulmonary disease-evaluation and management. Chest 1991; 99: 718-724.

Klinger, J.R., Moalli, R. Warburton, R.R., Wrenn, D.S. and Hill N.S. C-receptor ligand blocks pulmonary clearance of artial natriuretic peptide in isolated rat lungs. Proc Cos Exp Biol Med 1992; 201:154-158.

Klinger, J.R., Petit, R.D., Curtin. L.A., Warburton, R.R., Wrenn, D.S., Steinhelper, M.E., Field, L.J., and Hill, N.S. Cardiopulmonary responses to chronic hypoxia in transgenic mice that overexpress atrial natriuretic peptide. J. Appl Physiol 1993; 75:198-205.

Klinger, J.R., Petit, R.D., Warburton, R.R., Wrenn, D.S. and Hill, N.S. Neutral endopeptidase inhibition attenuates the development of hypoxic pulmonary hypertension in rats. J. Appl. Physiol 1993;75:1615-1623.

Hill, N.S., Klinger J.R., Warburton, RR, Pietras, L., Wrenn, D.S. Brain natriuretic peptide: Possible role in the modulation of hypoxic pulmonary hypertension. Am. J Physiol-Lung Cell Mol Physiol 1994; 266:L308-L315

Klinger, J.R., Arnal F., Warburton, R.R., Ou L-C, and Hill, N.S. Down-regulation of pulmonary artrial natriuretic peptide receptors in rats exposed to chronic hypoxia. J. Appl. Physiol (1994).

Brem, A.S., Bina, R.V., Klinger, J.R., Pietras, L., King, T, and Werner, J.C. Cluccocorticoid metabolism in the newborn rat heart. Proc Soc Exp Biol Med 209: 146-151 (1995)

Colice, G.L., Hill, N..S., Lee, Y-J, Du, H., Klinger, J.R., Leiter, and Ou, L-C. Exaggerated pulmonary hypertensive response to monocrotaline in rats susceptible to chronic mountain sickness. J. Appl Physiol 83: 25-31, 1997.