Thais Salazar-MatherPhoto of Dr. Salazar-Mather

Assistant Professor (Research)
Ph.D., Marshall University School of Medicine, Huntington, WV, 1992
Brown University
Bio-Med Center, 629
Phone: 401-863-9775
Fax: 401-863-1971
Email: [email protected]		 Our research interests revolve around understanding viral pathogenic mechanisms at the molecular level, and the interaction of viruses with the host immune system. Studies have focused on the in vivo role of early virus-induced cytokines and chemokines on natural killer (NK) cell trafficking to anatomical sites to deliver immune functions. This work has identified unique trafficking patterns in the spleen in response to interferons, and a novel chemokine-dependent mechanism for NK cell trafficking to the liver. Many basic techniques in cellular immunology, virology, molecular biology, histology and in vivo trafficking assays are being used to further understand inflammatory and protective responses in tissues. Current studies are aimed at defining the molecular events controlled by cytokines and chemokines for the delivery of immune cell functions to different anatomical sites and evaluating antiviral events mediated by chemokines. Information resulting from these studies will yield significant novel information for developing antiviral and anticancer treatment protocols.

SELECTED PAPERS

Salazar-Mather, T.P., C.A. Lewis, and C.A. Biron. Type 1 interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1α delivery to the liver. J. Clin. Invest. 110:321-330, 2002.

Dalod, M., T.P. Salazar-Mather, L. Malmgaard, C.A. Lewis, and C.A. Biron. IFN-α/β and IL-12 responses to viral infections: Pathways regulating dendritic cell cytokine expression in vivo. J. Exp. Med. 195:517-528, 2002.

Malmgarrd, L., T.P. Salazar-Mather, C.A. Lewis, and C.A. Biron. Pathways to IFN-α/β induction in vivo during viral infection. J. Virol. 76:4520-4525, 2002.

Salazar-Mather, T.P., T.A. Hamilton, and C.A. Biron. A chemokine-to-cytokine-to chemokine cascade critical in antiviral defense. J. Clin. Invest. 105:985-993, 2000.

Salazar-Mather, T.P., J.S. Orange, and C.A. Biron. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1 α (MIP-1α)-dependent pathways. J. Exp. Med. 187:1-14, 1998.

Biron, C.A., M. Dalod, and T.P. Salazar-Mather. Innate Immunity and Viral Infections. In: Immunology of Infectious Diseases, S.H.E. Kaufmann, A. Sherr, and R. Ahmed, eds., American Society for Microbiology Press, Washington, D.C., p. 139-160, 2001.

Biron, C.A., K.B. Nguyen, G.C. Pien, L.P. Cousens, and T.P. Salazar-Mather. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Ann. Rev. Immunol. 17:189-220, 1999.

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Brown University | MMI Department | Pathobiology Graduate Program | Program in Biology

This page was last modified on September 18, 2002.