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Computer models reveal an essential function of the spleen

Computer models developed by Brown researchers reveal an essential function of the spleen

Computer models developed at Brown show how red blood cells pass through tiny openings in the spleen, revealing that the limitations imposed by these openings determine the size of red blood cells. MIT/CMU/BrownComputer models developed at Brown show how red blood cells pass through tiny openings in the spleen, revealing that the limitations imposed by these openings determine the size of red blood cells. MIT/CMU/Brown

A new paper published in the Proceedings of the National Academy of Sciences reveals striking evidence that the spleen has a major role in determining the size of red blood cells, ensuring that they are able to pass safely through even the smallest of capillaries in the body.  This research is a joint effort of researchers from MIT, Carnegie Mellon and Brown University. George Em Karniadakis, Professor of Applied Mathematics at Brown University coauthored this important work, and developed the computer models foundational to this discovery.  (Read more.)