Invasive squamous cell carcinoma (cervix)

Invasive SCC is the end result of a process, usually due to infection with human papilloma virus, which proceeds from normal endocervical columnar epithelium to squamous metaplasia to varyng degrees of dysplasia, including SCC in-situ, to invasive SCC. The cells are usually large. They can be well-differentiated and keratinizing or moderately-differentiated and non-keratinizing.