Research Research Projects

Movement disorders: Rational design of DBS with human electrophysiology and computational neural modeling

Deep brain stimulation (DBS) is an electrical therapy that can help to alleviate symptoms of movement disorders like Parkinson's disease, Essential Tremor, and dystonia. Despite its clinical successes, how DBS works is not fully understood. We are collaborating to improve DBS efficacy by integrating human brain recordings collected during DBS surgery and biophysically principled modeling of the circuits impacted by DBS. Our experiments are designed to increase basic understanding of the neurophysiological substrates of normal and pathological movement in the human brain, and to use this information to guide improved treatments.

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Mesh reconstruction of ventral intermediate nucleus of the thalamus from fused MRI and CT with diffusion-based tractography. DBS electrode is shown in gray and tracts in blue. Credit: P. Lauro