The Department of Chemistry presents Professor Catherine L. Drennan as our inaugural Distinguished Women in Science seminar series speaker. Prof. Drennan is a Professor of Chemistry and Biology at MIT and a Principal Investigator for the Howard Hughes Medical Institute. The Drennan Research Laboratory seeks to understand how Nature harnesses and re-directs the reactivity of enzyme metallocenters in order to perform challenging reactions. The Drennan Education Laboratory creates resources for the innovative teaching of freshman chemistry. Learn more >>
All are invited to attend her seminar. There will be time for Q&A after the presentation.
Shake, Rattle & Roll: Capturing Snapshots of Metalloproteins in Action
Friday, October 13, 2017
4:00 PM, MacMillan Hall 115
Metalloproteins are responsible for remarkable catalytic conversions such as the reduction of ribonucleotides, the splitting of dinitrogen, and the fixation of carbon. Here the conformational gymnastics involved in ribonucleotide reduction by ribonucleotide reductases (RNRs) will be discussed. RNRs are key players in nucleic acid metabolism, converting ribonucleotides to deoxyribonucleotides. As such, they maintain the intracellular balance of deoxyribonucleotides to ensure the fidelity of DNA replication and repair. The best-studied RNR is the Fe-dependent enzyme from E. coli, which employs two protein-subunits to catalyze its reaction. Applications of biophysical methods to the study of RNRs have revealed the importance of subunit oligomeric state to overall enzyme activity, and suggest that dramatic protein conformational changes are in play.