Regulatory Information Encoded in Developmental Gene Regulatory Networks

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Wednesday, September 14, 2016 4:00pm - 5:00pm
Watson CIT - SWIG Boardroom (CIT241)

Dr. Isabelle Peter
Assistant Professor of Biology & Biological Engineering
California Institute of Technology

Gene regulatory networks control developmental process at many scales of structural organization. They determine the expression of individual genes throughout development, in response to changing regulatory contexts, and encode more complex regulatory functions such as stabilization, exclusion, memory, or quality control, at the level of network subcircuits. Within large scale developmental networks, regulatory information is integrated at all levels. We have in the past developed a Boolean model to test the function of the large scale sea urchin endomesoderm network, and are now using this approach to assess the regulatory information encoded in specific circuit configurations such as the coherent feedforward subcircuit that occur frequently in developmental networks. I will discuss several examples of experimentally well characterized network circuitry, with a focus on the structural properties that determine their specific developmental function.

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