Lauren Alpert Sugden (Ramachandran Lab)
I study the patterns left behind by natural selection on human genomes, focusing on adaptive events that influence such phenotypes as lactase persistence and light skin pigmentation in European populations, and defense against malarial infection in West African populations. Drawing from the broad fields of probability and statistics, I am developing methods for predicting new phenotypes (and underlying genomic loci) that have undergone strong positive selection in the human lineage in a way that is robust and interpretable. I am also interested in models of human population expansion over the last 100 thousand years, and the global and local genomic patterns that result from migration, population bottlenecks, and admixture with archaic hominins.
Carolyn Eng (Roberts Lab)
I am interested in the influence of elastic connective tissues on the energetics and mechanics of muscle function. In my previous work, I explored the role of fascia in movement by studying its biaxial material properties and in vivo strain patterns. I used these data to incorporate the iliotibial band into a musculoskeletal model of the human lower limb to understand its role in human locomotion. With my postdoctoral research in the Roberts lab, I am exploring the role of aponeurosis in modulating muscle function. By modifying aponeurosis properties, I will directly examine the role of aponeurosis in modulating muscle shape changes and test how similar alterations occurring after surgical intervention or with injury, age, or disease influence the mechanics of muscle contraction.
Eric Goolsby (Edwards Lab)
I study macroevolution at both the phenotypic and molecular levels in a variety of frameworks, including phylogenetic comparative methods development for complex multivariate traits, plant ecophysiology, and phylogenomics approaches. I'm currently investigating the complex evolutionary history of C4 and CAM photosynthesis evolution in the genus Portulaca. I'm also studying the evolutionary dynamics of heavy metal tolerance and hyperaccumulation in the a function-valued framework, using the sunflower genus (Helianthus) as a study system.
Google Scholar: https://scholar.google.com/citations?user=bbEJDSQAAAAJ
Sarah Ivory (Sax Lab)
I am interested in changes in tropical biodiversity and vegetation responses to climate in the past, present, and future. I use fossil pollen records over thousands to millions of years in the past to look at changing species assemblages over time and better understand natural and anthropogenic controls on vegetation structure. I also use ecological models to provide a quantitative framework for evaluating how future climate change is likely to affect tropical forests. A better understanding of these forests, some of the world’s biodiversity hotspots, is crucial in order to inform conservation and management practices. In combining fossil pollen based vegetation reconstructions and ecological models using current species maps, I can evaluate potential range changes and identify at-risk areas.
Zachary Lewis (Dunn & Edwards Lab)
Juan Losada (Leslie Lab)
Chintan Modi (Weinreich Lab)
I am interested in understanding the evolution of structure-function relationship of proteins. Specifically, I am working to understand how novel biochemical function evolves. Currently I am studying the emergence of antibiotic resistance by asking how a novel ß-lactamase function evolved from penicillin-binding proteins (PBPs). Part of this study also plans to understand the evolution of generalist vs. specialist ß-lactamases. To answer these questions I am plan to use directed evolution and ancestral reconstruction through statistical phylogenetic methods. I also remain interested in understanding the evolution of homo-oligomerization. Prior to join the Weinreich lab, I studied the evolutionary biochemistry of the GFP-family of proteins using resurrected ancestral fluorescent proteins. My research help elucidate the initial historical mutations needed to enable the evolution of novel biochemical step in emergence of red fluorescence in Kaede FPs and showed evolution of diverse homo oligomers from an ancestral monomer the hydrozoan FPs.
Sabine Moritz (Brainerd Lab)
I have always been interested in the interplay between skeleton and musculature. Right now I am using XROMM to explore the relationship between musculo-skeletal morphology and function in several non-mammalian amniotes.
Jim Mossman (Rand Lab)
I am interested in how mitochondrial and nuclear genomes interact to mediate organismal fitness. Central foci of my research include: (i) mitochondrial genetic variation and male-specific traits (Frank and Hurst Hypothesis), (ii) G x G interactions (mtDNA-nDNA epistases), and (iii) G x G x E effects on phenotypic variation and gene expression. I currently use Drosophila to investigate these phenomena.
Yevgeniy "Eugene" Raynes (Weinreich Lab)
I use experimental evolution and computer simulations to study evolution of the genomic mutation rate. During my PhD I studied the evolutionary dynamics of mutator alleles in experimental microbial populations, focusing on indirect selection experienced by mutators due to their associations with beneficial mutations. Currently, I am using computer simulations to examine the evolutionary dynamics of chromosomal instability during cancer progression.
Michael Rosario (Roberts Lab)
Across the tree of life, the storage and release of elastic energy aids organismal movement. In some cases, elastic elements are used to amplify power (e.g., tendon storing energy and releasing quickly while jumping) and in others, they can attenuate impacts (by releasing energy to muscle over a relatively long period of time). In these examples, the function of elastic elements depends on 1) the relative speed of loading to unloading and 2) the nature of the connected structures. In my research, I combine mechanical testing with computer simulation to study the dynamic interaction between springs and their connected structures. Recently, I developed dynamic muscle-spring simulations of bullfrogs and grasshoppers to investigate the effects of time constraint on tendon stiffness. Currently, I am characterizing the effects of stress-rate on energy storage and dissipation in the tendon fascicles of rat tails.