Brown University School of Engineering

Engineering Seminar: Biomedical Engineering

Add event to my Google calendar Add event to my Google calendar Share this event on facebook E-mail this event
Thursday, December 07, 2017 3:00pm - 4:00pm

Professor Antonio J. Salgado, Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal will present a talk: "Shaping CNS Repair through the Combinatory Action of Stem Cells Secretome and ECM-like Hydrogels." Abstract: The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders, namely due to the beneficial actions of their secretome. Indeed, the latter possesses a broad range of neuroregulatory factors that promote an increase in neurogenesis, inhibition of apoptosis/glial scar, immunomodulation, angiogenesis, neuronal and glial cell survival, as well as relevant neuroprotective actions into different pathophysiological contexts. Considering their protective action in lesioned sites, MSCs, and their secretome, might also improve the integration of local progenitor cells in neuroregeneration processes. In this sense their use could represent an important vehicle for the establishment of future CNS regenerative therapies. In the present talk the role of MSCs, and their secretome, on phenomena such as in vitro and in vivo neuronal/glial survival will be addressed. Additionally, their possible applications, alone or combined with ECM-like hydrogels, for Parkinson’s Diseases and Spinal Cord Injury regenerative medicine will also be presented. Finally, new trends on how to modulate the secretome MSCs will also be presented. Bio: António Salgado is a biologist and received is PhD in Materials Science and Engineering- Tissue Engineering and Hybrid Materials, from the University of Minho in 2005, followed by a post-doc at the University of Toronto and Life and Health Sciences Research Institute (ICVS) at University of Minho, dedicated to CNS regenerative medicine. Currently he is a PrincipaI Investigator at the Life and Health Sciences Research Institute (ICVS) and an Adjunct Associate Professor in the School of Medicine, University of Minho. His research interests are focused on the development of innovative therapies for CNS repair, namely on Spinal Cord Injury and Parkinson’s Disease. His main areas of research are: 1) Development of ECM like hydrogels for the transplantation of Mesenchymal Stem Cells into the injured CNS; 2) Role of the secretome of MSCs in neuroprotection and repair, particularly the establishment of novel therapies based on the sole use of MSCs secretome. He is currently an author of more than 80 papers (over 2800 citations; h-Index=25). Presently he is the coordinator of the Portuguese Network for Spinal Cord Injury Research and director of the Spinal Cord Injury Initiative @ ICVS (SCICVS).