Dr Jay's Lab: Musculoskeletal Trauma Lab
The Department of Emergency Medicine has an established laboratory located on the Rhode Island Hospital campus in CORO West, Suite 4.303. This laboratory is staffed by investigators from the Department of Emergency Medicine and the Brown University Division of Engineering. Research activities are focused on Bio-Engineering and Biophotonics Projects which are translationally important to the care of Emergency Medicine patients.
Investigators and Collaborators
Gregory D. Jay, MD, PhD
Dr. Jay is a professor in the Department of Emergency Medicine and Division of Engineering at Brown University. He also serves as an adjunct professor in the Department of Biomedical Sciences at the University of Rhode Island. In addition to his academic activities, he brings over 15 years of experience as an emergency medicine physician, and he is currently employed in that capacity by University Emergency Medicine Foundation, practicing at Rhode Island Hospital and Miriam Hospital in Providence, Rhode Island. Dr. Jay, who holds an MD, PhD (in experimental pathology) and double bachelor's degrees (in engineering and biochemistry) from State University of New York at Stony Brook, is a member of numerous professional societies and is a journal reviewer for several journals in the fields of engineering, emergency medicine, and several other medical specialties. He holds over a dozen issued patents and pending patent applications covering diverse technologies in pulsus paradoxus monitoring and the lubrication of mammalian joints. He has published 70+ articles in medical and scientific journals and is a recipient of support from NIH. He is co-editor of "Liquid Crystals: Frontiers in Biomedical Applications" (World Scientific Press, 2007).
Selim Suner, MD
Dr. Suner graduated from Alpert Medical School after completing a master's degree in biomedical engineering at Brown University. Dr. Suner, who is on the staff at Rhode Island Hospital, and the director of Disaster Medicine and Emergency Preparedness in the Department of Emergency Medicine, completed the Brown University/Rhode Island Hospital Residency Program in Emergency Medicine. Dr. Suner, currently an associate professor of emergency medicine, surgery and engineering at Brown University, was awarded the SAEM Neuroscience Fellowship for 2003-2004 and has received the "Best Scientific Presentation" award from the Society of Academic Emergency Medicine (SAEM) in 1999 and 2004. Dr. Suner is the leader of the Rhode Island Disaster Medical Assistance Team (DMAT), and he has served during multiple disaster deployments including the responses to Hurricane Katrina, the World Trade Center attacks and the Egypt Air crash off the shores of Massachusetts. Dr Suner also serves as chairman of Rhode Island Hospital Emergency Preparedness Committee and participates in many national and state level committees working on disaster preparedness. Dr Suner is an international expert in emergency preparedness and disaster medicine and has given over a 100 lectures related to disaster management, world-wide. Dr. Suner has published many peer reviewed scientific manuscripts and abstracts. He is a peer reviewer for 4 scientific journals and is on the editorial board of emedhome.com, an educational website for emergency physicians and the Turkish Journal of Emergency Medicine. Dr. Suner is also an associate editor of the textbook "Disaster Medicine" (Mosby, 2006).
Ling Zhang, MD
Dr. Ling Zhang is a senior research scientist in the Department of Emergency Medicine, Rhode Island Hospital. She received her MD from Henan Medical University in China. She worked as a research associate and was trained as a molecular and cellular scientist in the Department of Pharmacology and Toxicology at the Virginia Commonwealth University. Dr. Zhang was then appointed as a specialist to study immunology and toxicology. Prior to joining the Department of Emergency Medicine, she was the laboratory manager and senior research scientist investigating molecular mechanism(s) of inter-alpha inhibitor proteins in sepsis in the Department of Medicine at Rhode Island Hospital. Currently, Dr. Zhang is working in Dr. Jay's laboratory studying the molecular signaling pathway of Lubricin in mediating chondroprotection of diarthrodial joints. She has published 20 articles in medical and biological journals. Her primary expertise includes: cell and tissue culture, bone marrow culture, monoclonal antibody production, immunoblotting, ELISA, protein purification, molecular cloning, mutagenesis, siRNA, RNase protection assay, immunostaining, histology, flow cytometry, animal surgery, breeding and genotyping.
Kim Waller, BS
Kimberly Waller is a doctoral student in biomedical engineering at Brown University. She received her bachelor's degree in biomedical engineering from Boston University in 2008. She has interned at Boston Scientific Corporation and worked as a research assistant in the Research for Undergraduates program at Boston University in the Organogenesis Laboratory. Her current research topics include articular joint lubrication and chondroprotection, specifically in the case of ACL injury, using both animal and in vitro models.
- Division of Biology and Medicine at Brown
- Alpert Medical School
- John Donoghue's Laboratory (Selim Suner, MD collaboration)
- Center for Biomedical Engineering
What's Happening in the Lab?
Research Developments in the Laboratory
Recent Notable Publications
- Aninewene, GE., Yang, Z., Ravi, V., Jay, G., Webster, T. Lubricin as a novel nanostructured protein coating to reduce fibroblast density. International Journal of Nanomedicine. 2014 Jun 25;9:3131-5. [PMID: 25028550] [PMCID: PMC4077603]
- Jay, G., Waller, K. The Biology of Lubricin: Near Frictionless Joint Motion. Matrix Biology. 2014 Oct;39C:17-24. [PMID: 25172828]
- Zhao C, Ozasa Y, Reisdorf RL, Thoreson AR, Jay GD, An K, Amadio PC. Engineering Flexor Tendon Repair With Lubricant, Cells, and Cytokines in a Canine Model. Clininal Orthopeadic Related Research. 2014 Sep;472(9):2569-78. [PMID:24906811] [PMCID: PMC4117902]
- Elsaid, K., Zhang, L., Shaman, Z., Patel, C., Schmidt, TA., Jay, GD. The Impact of Early Intra-Articular Administration of Interleukin-1 Receptor Antagonist on Lubricin Metabolism and Cartilage Degeneration in an Anterior Cruciate Ligament Transection Model. Osteoarthritis Cartilage. 2015 Jan;23(1):114-21.
- Ai, M., Cui, Y., Sy, M., Lee, DM., Zhang, LX., Larson, KM., Kurek, KC., Jay, GD., Warman, ML. Anti-Lubricin Monoclonal Antibodies Created Using Lubricin-Knockout Mice Immunodetect Lubricin in Several Species and in Patients with Healthy and Diseased Joints. PLOS One. 2015 Feb 2;10(2). [PMID:25642942]
- Iqbal SM, Leonard C, Regmi S, De Rantere D, Tailor P, Ren G, Ishida H, Hsu CY, Abubacker S, Pang DSJ, Salo P, Vogel HJ, Hart DA, Waterhouse CC, Jay GD, Schmidt TA, Krawetz RJ. Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like receptors in vitro. Scientific Reports. 2015 Nov. DOI:10.1038/srep18910
- Alquraini A, Graguilo S, D’Souza G, Schmidt TA, Jay GD, Elsaid KA. The Interaction of Lubricin/Proteoglycan 4 (PRG4) with Toll-like Receptors 2 and 4: An Anti-inflammatory Role of PRG4 in Synovial Fluid. Arthritis Research and Therapy. 2015 Dec 4;17:353.