Chiung-kuei Huang, PhD

Assistant Professor of Medicine (Research)

Phone: 401-444-7441

Email: [email protected]

Research Interests

My research interests focus on the molecular pathogenesis of liver cancers. ASPH is an enzyme that functions by hydroxylating aspartic acid and asparagine residues in epidermal growth factor (EGF)-like domains of various signaling molecules including Notch1, which has been shown to involve in cancer stem cell, cancer migration, invasion, and proliferation. ASPH has been shown to overexpress on the cell surface of 97% of cholangiocarcinoma but not in adjacent normal bile ducts. In addition, our studies demonstrated that 87% of hepatocellular carcinoma and 98% of pancreatic cancer patients have ASPH overexpression, suggesting that ASPH may be an important feature of the malignant phenotype and may be involved in the development and progression malignant tumors. However, the molecular mechanism by which ASPH modulates liver cancer progression is not clear. Clarification of molecular mechanism by which ASPH involves in cancer progression may provide the potential therapeutic approach in treating cancer. In our lab, we will use a gain of function and loss of function strategies to clarify how ASPH involves in malignant tumor progression.

Selected Publications

Ethanol consumption associated hepatocyte apoptosis links to decreased TET1 and 5-hydroxymethylcytosine in alcoholic liver disease.  Ji C*, Nagaoka K*,  Zou J*, Casulli S, Iwagami Y, Lu S, Carlson R, Cao KY, Zhang H, Mueller Billy, Brooks K, Lawrence J, Wands JR, Huang CK.  FASEB J. 2018 Sep 6:fj201800736R. doi: 10.1096/fj.201800736R. [Epub ahead of print]

Alanine-Glyoxylate Aminotransferase 1 (AGXT1) is a Novel Marker for Hepatocellular Carcinomas. Zhao CL, Hui Y, Wang JL, Yang D, Yakirevich E, Mangray S, Huang CK#, Lu S# (# co-corresponding authors).  Hum Pathol. 2018 Jun 5. pii: S0046-8177(18)30193-X. doi: 10.1016/j.humpath.2018.05.025. [Epub ahead of print]

Alcohol-mediated miR-34a modulates hepatocyte growth and apoptosis. Iwagami I*, Zou J* (* Contributed equally), Zhang H, Cao K, Ji C, Kim M, Huang CK. J Cell Mol Med. 2018 Jun 5. doi: 10.1111/jcmm.13681. [Epub ahead of print]

Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation. Huang CK*, Iwagami Y*, Zou J*, Casulli S, Lu S, Nagaoka K, Ji C, Ogawa K, Cao KY, Gao JS, Carlson R, Wands JR. Cancer Lett. 2018 May 5;429:1-10. doi: 10.1016/j.canlet.2018.04.041 (*Contributed equally)

Aspartate-hydroxylase modulates cellular senescence via the glycogen synthase kinase 3 beta in hepatocellular carcinoma.  Iwagami Y*, Huang CK* (*Contributed equally), Olsen MJ, Thomas JM, Jang G, Kim M, Lin Q, Carlson RI, Wagner CE, Dong X, Wands JR.  Hepatology. 2016 Apr;63(4):1213-26. doi: 10.1002/hep.28411. Epub 2016 Feb 19